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Contribution of Inbred Singletons to Variance Component Estimation of Heritability and Linkage.
Human Heredity ( IF 1.8 ) Pub Date : 2018-11-06 , DOI: 10.1159/000492830
Lucy Blondell 1 , August Blackburn 2 , Mark Z Kos 2 , John Blangero 2 , Harald H H Göring 2
Affiliation  

OBJECTIVES An interesting consequence of consanguinity is that the inbred singleton becomes informative for genetic variance. We determine the contribution of an inbred singleton to variance component analysis of heritability and linkage. METHODS Statistical theory for the power of variance component analysis of quantitative traits is used to determine the expected contribution of an inbred singleton to likelihood-ratio tests of heritability and linkage. RESULTS In variance component models, an inbred singleton contributes relatively little to a test of heritability but can contribute substantively to a test of linkage. For small-to-moderate quantitative trait locus (QTL) effects and a level of inbreeding comparable to matings between first cousins (the preferred form of union in many human populations), an inbred singleton can carry nearly 25% of the information of a non-inbred sib pair. In more highly inbred contexts available with experimental animal populations, nonhuman primate colonies, and some human subpopulations, the contribution of an inbred singleton relative to a sib pair can exceed 50%. CONCLUSIONS Inbred individuals, even in isolation from other members of a sample, can contribute to variance component estimation and tests of heritability and linkage. Under certain conditions, the informativeness of the inbred singleton can approach that of a non-inbred sib pair.

中文翻译:

近交单身人士对遗传力和连锁性方差成分估计的贡献。

目的血缘关系的一个有趣的结果是,近交单身人士可以为遗传变异提供信息。我们确定近交单身人士对遗传力和连锁性的方差成分分析的贡献。方法采用统计理论对数量性状的方差成分分析的力量来确定近交单身人士对遗传力和连锁度的似然比检验的预期贡献。结果在方差成分模型中,近交单身人士对遗传力测验的贡献相对较小,但对关联性测验的贡献却很大。对于中小数量性状基因座(QTL)的影响以及近亲交配的水平,可以与第一亲戚之间的交配相媲美(在许多人群中,这种结合的首选形式),近交单身人士可以携带近交同胞对的近25%的信息。在具有实验动物种群,非人类灵长类动物群落和某些人类亚种群的更高近交背景下,近交单身人士相对于同胞对的贡献可能超过50%。结论自交个体,即使与样本的其他成员隔离,也可以有助于方差成分估计以及遗传力和连锁性的测试。在某些条件下,近交单身人士的信息量可以接近非近交同胞对的信息量。结论自交个体,即使与样本的其他成员隔离,也可以有助于方差成分估计以及遗传力和连锁性的测试。在某些条件下,近交单身人士的信息量可以接近非近交同胞对的信息量。结论自交个体,即使与样本的其他成员隔离,也可以有助于方差成分估计以及遗传力和连锁性的测试。在某些条件下,近交单身人士的信息量可接近非近交同胞对的信息量。
更新日期:2019-11-01
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