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Effects of a high-cultivation temperature on the physiology of three different Yarrowia lipolytica strains.
FEMS Yeast Research ( IF 3.2 ) Pub Date : 2019-11-01 , DOI: 10.1093/femsyr/foz068
S Hackenschmidt 1 , F Bracharz 1 , R Daniel 2 , A Thürmer 3 , S Bruder 1 , J Kabisch 1
Affiliation  

Despite the increasing relevance, ranging from academic research to industrial applications, only a limited number of non-conventional, oleaginous Yarrowia lipolytica strains are characterized in detail. Therefore, we analyzed three strains in regard to their metabolic and physiological properties, especially with respect to important characteristics of a production strain. By investigating different cultivation conditions and media compositions, similarities and differences between the distinct strain backgrounds could be derived. Especially sugar alcohol production, as well as an agglomeration of cells were found to be connected with growth at high temperatures. In addition, sugar alcohol production was independent of high substrate concentrations under these conditions. To investigate the genotypic basis of particular traits, including growth characteristics and metabolite concentrations, genomic analysis were performed. We found sequence variations for one third of the annotated proteins but no obvious link to all phenotypic features.

中文翻译:

高温培养对三种不同解脂耶氏酵母菌株的生理学的影响。

尽管从学术研究到工业应用的相关性越来越高,但仅详细描述了有限数量的非常规的,产油的解脂耶氏酵母菌株。因此,我们分析了三种菌株的代谢和生理特性,特别是生产菌株的重要特征。通过研究不同的栽培条件和培养基组成,可以得出不同菌株背景之间的相似性和差异。特别是糖醇的产生以及细胞的聚集被发现与高温下的生长有关。另外,在这些条件下,糖醇的生产与高底物浓度无关。为了研究特定性状的基因型基础,包括生长特性和代谢物浓度,进行了基因组分析。我们发现有注释的蛋白质的三分之一有序列变异,但与所有表型特征均无明显联系。
更新日期:2019-11-01
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