Increased plasma concentration of asymmetric dimethylarginine (ADMA) can be encountered in chronic inflammatory disease, liver damage, renal failure, and multiple organ failure. In addition, an association between circulating ADMA and all‐cause mortality has been reported. Male Sprague‐Dawley rats, postnatal day (PND) 17 ± 1, received continuous ADMA infusion via an intraperitoneal pump. Spatial performance, as well as plasma and dorsal hippocampus ADMA and brain‐derived neurotrophic factor (BDNF) concentration, were examined and the effect of melatonin was tested. We found that a 4‐week continuous ADMA infusion in young rats caused spatial deficit. Furthermore, increased ADMA concentration and decreased BDNF expression were found in the plasma and dorsal hippocampus. Melatonin protected against these effects, alleviating spatial deficit and reducing the changes in plasma and dorsal hippocampus ADMA and BDNF concentration.

中文翻译：

---

循环不对称二甲基精氨酸增加的幼鼠表现出背海马脑源性神经营养因子和不对称二甲基精氨酸的空间缺陷和改变：褪黑激素的影响

在慢性炎症性疾病、肝损伤、肾功能衰竭和多器官功能衰竭中可能会遇到不对称二甲基精氨酸 (ADMA) 血浆浓度升高。此外，已有报道称循环 ADMA 与全因死亡率之间存在关联。雄性 Sprague-Dawley 大鼠，出生后天数 (PND) 17 ± 1，通过腹腔泵连续输注 ADMA。检查了空间表现，以及血浆和背侧海马 ADMA 和脑源性神经营养因子 (BDNF) 浓度，并测试了褪黑激素的作用。我们发现在幼鼠中连续 4 周输注 ADMA 会导致空间缺陷。此外，在血浆和背侧海马中发现 ADMA 浓度增加和 BDNF 表达降低。褪黑激素保护免受这些影响，