Acute myeloid leukemia (AML) is a heterogeneous disease whose therapies currently show elevated toxicity and a high rate of relapse. Recently, the burgeoning of new anti-tumor therapeutic strategies aimed at enhancing the immune response has pushed natural killer cells (NKs) into the spotlight. These cells are powerful warriors that can bring about the lysis of tumor cells through their cytotoxic ability. However, tumor cells have developed strategies to evade recognition mediated by NKs. Here, we review the mechanisms triggered by AML cells and discuss the emerging immunotherapeutic strategies that potentiate the anti-tumor functions of NKs.

中文翻译：

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急性髓细胞性白血病和NK细胞：两个战士面对面。

急性髓细胞性白血病（AML）是一种异质性疾病，其疗法目前显示出较高的毒性和较高的复发率。最近，旨在增强免疫反应的新抗肿瘤治疗策略的兴起使自然杀伤细胞（NKs）受到关注。这些细胞是强大的战士，可以通过其细胞毒性能力来裂解肿瘤细胞。然而，肿瘤细胞已经开发出逃避NK介导的识别的策略。在这里，我们审查由AML细胞触发的机制，并讨论增强NKs的抗肿瘤功能的新兴免疫治疗策略。