Human stem cell-based therapeutic intervention strategies for treating HIV infection have recently undergone a renaissance as a major focus of investigation. Unlike most conventional antiviral therapies, genetically engineered hematopoietic stem cells possess the capacity for prolonged self-renewal that would continuously produce protected immune cells to fight against HIV. A successful strategy therefore has the potential to stably control and ultimately eradicate HIV from patients by a single or minimal treatment. Recent progress in the development of new technologies and clinical trials sets the stage for the current generation of gene therapy approaches to combat HIV infection. In this review, we will discuss two major approaches that are currently underway in the development of stem cell-based gene therapy to target HIV: one that focuses on the protection of cells from productive infection with HIV, and the other that focuses on targeting immune cells to directly combat HIV infection.

中文翻译：

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基于干细胞的抗 HIV 基因疗法。

用于治疗 HIV 感染的基于人类干细胞的治疗干预策略最近作为研究的主要焦点经历了复兴。与大多数传统抗病毒疗法不同，基因工程造血干细胞具有长期自我更新的能力，可以持续产生受保护的免疫细胞来对抗 HIV。因此，成功的策略有可能通过单一或最低限度的治疗稳定控制并最终从患者身上根除 HIV。新技术开发和临床试验的最新进展为当前抗击 HIV 感染的基因治疗方法奠定了基础。在这篇综述中，我们将讨论目前在开发基于干细胞的针对 HIV 的基因疗法的两种主要方法：