Uveitis is an inflammatory disease associated with diverse systemic and autoimmune diseases, defined as the inflammation of any given segment of the uveal tract, uveitis contributes with 5-20% cases of blindness in the USA/Europe and >25% of cases in third-world countries. To understand its pathogenic mechanisms, BALB/c and C57BL/6 mice were induced to develop the condition by a single intraperitoneal injection of E. coli lipopolysaccharide, the aim of the present work is to determine leukocyte infiltration in an endotoxin-induced uveitis (EIU) in two non-related mouse strains. Histopathological findings and clinical analysis were conducted 24 and 48 h postinjection. Both strains presented conventional clinical signs of uveitis 24 h post LPS injection and the highest inflammatory leukocyte infiltration in the uveal tract was found in the BALB/c mouse strain. This article will give an insight on the difference of the inflammatory response in the EIU model in two different mouse strains and the relationship between the pathologic response.

中文翻译：

---

在内毒素诱导的葡萄膜炎模型中，BALB / c和C57BL / 6小鼠品系中炎症反应的比较分析。

葡萄膜炎是一种与多种系统性和自身免疫性疾病相关的炎性疾病，定义为葡萄膜任何特定部分的炎症。在美国/欧洲，葡萄膜炎导致5-20％的失明病例，在第三位病例中占25％以上的失明病例。世界国家。为了了解其致病机制，通过单次腹膜内注射大肠杆菌脂多糖诱导BALB / c和C57BL / 6小鼠发展这种疾病，本研究的目的是确定内毒素诱导的葡萄膜炎（EIU）中的白细胞浸润）在两个无关的小鼠品系中。注射后24和48小时进行组织病理学发现和临床分析。LPS注射后24小时，这两种菌株均表现出葡萄膜炎的常规临床体征，BALB / c小鼠品系中葡萄膜的炎症性白细胞浸润最高。本文将深入探讨两种不同小鼠品系的EIU模型中炎症反应的差异以及病理反应之间的关系。