Frontotemporal lobar degeneration (FTLD) consists of a clinically, pathologically and genetically heterogeneous group of neurodegenerative disorders that chiefly affect frontal and temporal lobes. Clinical presentation in FTLD includes behavioural variant frontotemporal dementia, progressive nonfluent aphasia and semantic dementia (SD). Pathologically, FTLD is subdivided based on accumulation of abnormal intracellular proteins including transactivation response DNA-binding protein 43 kDa (TDP-43) [1, 2]. TDP-43 pathology in FTLD is classified into five pathological subgroups depending on its morphological features: TDP-43 type A, B, C, D and E [2, 3].

中文翻译：

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额颞叶变性 TDP-43 C 型病理中的皮质脊髓束退变和颞叶萎缩

额颞叶变性 (FTLD) 由临床、病理和遗传异质性的一组神经退行性疾病组成，主要影响额叶和颞叶。FTLD 的临床表现包括行为变异额颞叶痴呆、进行性非流利性失语症和语义性痴呆 (SD)。在病理学上，FTLD 根据异常细胞内蛋白质的积累进行细分，包括反式激活反应 DNA 结合蛋白 43 kDa (TDP-43) [1, 2]。FTLD 中的 TDP-43 病理根据其形态特征分为五个病理亚组：TDP-43 A、B、C、D 和 E 型 [2, 3]。