The ATP binding cassette protein superfamily comprises ATPase enzymes which are, for the most part, involved in transmembrane transport. Within this superfamily however, some protein families have other functions unrelated to transport. One example is the ABC-F family, which comprises an extremely diverse set of cytoplasmic proteins. All of the proteins in the ABC-F family characterized to date act on the ribosome and are translation factors. Their common function is ATP-dependent modulation of the stereochemistry of the peptidyl transferase center (PTC) in the ribosome coupled to changes in its global conformation and P-site tRNA binding geometry. In this review, we give an overview of the function, structure, and theories for the mechanisms-of-action of microbial proteins in the ABC-F family, including those involved in mediating resistance to ribosome-binding antibiotics.

中文翻译：

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ABC-F蛋白在mRNA的翻译和抗生素耐药性。

ATP结合盒蛋白超家族包含ATP酶，这些酶大部分参与跨膜运输。但是，在这个超家族中，某些蛋白质家族具有与运输无关的其他功能。一个例子是ABC-F家族，它包含一组极为多样的细胞质蛋白。迄今表征的ABC-F家族中的所有蛋白质都作用于核糖体，并且是翻译因子。它们的共同功能是核糖体中肽基转移酶中心（PTC）立体化学的ATP依赖性调节，并与其整体构象和P位点tRNA结合几何形状发生变化。在这篇综述中，我们概述了ABC-F家族中微生物蛋白的作用机理的功能，结构和理论，