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Molecular evolution of the first cells
Pure and Applied Chemistry ( IF 1.8 ) Pub Date : 1973-01-01 , DOI: 10.1351/pac197334030641
S W Fox

The evolutionary sequence of galactic organic matter —* amino acids informational protoprotein —÷ protocell —* (nucleic acid-governed) contemporary cell is reviewed, and the supporting evidence is presented in outline. The experiments suggest that thermal polymerization of diverse ct-amino acids yielded partially-ordered protoproteins which possessed varied protoenzymic activities. These protoproteins assembled, according to the experiments, on simple contact with water to yield protocells. The model protocells contain enzyme-like activities, ultrastructure and selective membranes, and they have been found to reproduce in five modes, each of which is conceptually relatable as an evolutionary precursor to a contemporary mode of reproduction. The processes have been shown to be geologically relevant, imparting much rigour to the model. The simplicity of the formation of the protocellular model and the terrestrial ubiquity of water support the concept of protocells having arisen easily and often as protoprotein formed. These experiments and the dcrived theory required constructionistic processes based on knowledge obtained by reductionistic methods.

中文翻译:

第一个细胞的分子进化

回顾了银河有机质——*氨基酸信息原蛋白——÷原细胞——*(核酸控制的)当代细胞的进化序列,并概述了支持证据。实验表明,不同的 ct-氨基酸的热聚合产生了具有不同原酶活性的部分有序的原蛋白。根据实验,这些原蛋白在与水简单接触后组装起来,产生原细胞。模型原始细胞包含酶样活性、超微结构和选择性膜,并且已经发现它们以五种模式繁殖,每种模式在概念上都可以作为当代繁殖模式的进化先驱。这些过程已被证明与地质相关,赋予模型更多的严谨性。原始细胞模型形成的简单性和水在地球上的普遍存在支持了原始细胞的概念,即原始细胞很容易并且通常是作为原始蛋白形成的。这些实验和驱动理论需要基于通过还原方法获得的知识的构造过程。
更新日期:1973-01-01
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