Experimental results of the second series of experiments on the penetration of monodisperse polymeric particles, inhaled at low dose by mice, to different organs using direct way of particle registration, based on the ultra-sensitive accelerator mass-spectrometer (AMS), are presented. Polystyrene (PS) beads, composed of radiocarbon-labeled styrene, were produced for testing them as model organic aerosols. Mice inhaled 14 C-PS aerosol of 3·105 ultrafine particles per 1 cm3 for 30 minutes every day during five days. Long-term investigation showed that PS ultrafine particles have been effectively accumulated in lungs with the maximum content in the fifth day of postexposure, and have also appeared in liver on the fifth day of exposure and in the brain on the thirtieth day of experiments. No particles have been detected in kidneys, spleen and excrements. 35 millions of particles remained in the lungs after half a year of postexposure showing extremely slow removal of such particles from the organ.

中文翻译：

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小鼠低剂量吸入的超细有机气溶胶颗粒在肺部残留半年多

介绍了基于超灵敏加速器质谱仪 (AMS) 的第二系列实验的实验结果，该实验使用直接的粒子配准方式将小鼠低剂量吸入的单分散聚合物粒子渗透到不同器官。聚苯乙烯 (PS) 珠子由放射性碳标记的苯乙烯组成，用于测试它们作为模型有机气溶胶。在五天内，小鼠每天吸入 14 C-PS 气溶胶，每 1 cm3 含有 3·105 个超细颗粒，持续 30 分钟。长期调查表明，PS超细颗粒在暴露后第5天在肺中有效积累，含量最高，在暴露后第5天出现在肝脏中，在实验第30天出现在大脑中。在肾脏中未检测到颗粒，脾脏和排泄物。暴露后半年仍有 3500 万个颗粒留在肺中，这表明从器官中清除这些颗粒的速度极其缓慢。