The need for international collaboration in rodent pathology has evolved since the 1970s and was initially driven by the new field of toxicologic pathology. First initiated by the World Health Organization's International Agency for Research on Cancer for rodents, it has evolved to include pathology of the major species (rats, mice, guinea pigs, nonhuman primates, pigs, dogs, fish, rabbits) used in medical research, safety assessment, and mouse pathology. The collaborative effort today is driven by the needs of the regulatory agencies in multiple countries, and by needs of research involving genetically engineered animals, for "basic" research and for more translational preclinical models of human disease. These efforts led to the establishment of an international rodent pathology nomenclature program. Since that time, multiple collaborations for standardization of laboratory animal pathology nomenclature and diagnostic criteria have been developed, and just a few are described herein. Recently, approaches to a nomenclature that is amenable to sophisticated computation have been made available and implemented for large-scale programs in functional genomics and aging. Most terminologies continue to evolve as the science of human and veterinary pathology continues to develop, but standardization and successful implementation remain critical for scientific communication now as ever in the history of veterinary nosology.

中文翻译：

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实验动物的当前标准和组织病理学术语的发展回顾。

自1970年代以来，在啮齿类动物病理学领域进行国际合作的需求就不断发展，最初是由毒理学病理学的新领域推动的。它最初是由世界卫生组织的国际啮齿动物癌症研究机构发起的，现已演变为包括用于医学研究的主要物种（大鼠，小鼠，豚鼠，非人类灵长类动物，猪，狗，鱼，兔子）的病理学，安全性评估和小鼠病理学。当今的合作努力是由多个国家监管机构的需求以及涉及基因工程动物的研究需求，“基础”研究以及人类疾病的更多临床前临床模型驱动的。这些努力导致建立了国际啮齿动物病理学术语计划。从那之后，已经开发了用于实验室动物病理学命名和诊断标准标准化的多种协作，这里仅描述其中的几种。近来，适用于复杂计算的命名法的方法已经可用，并已用于功能基因组学和老化的大规模程序。随着人类和兽医病理学的不断发展，大多数术语都在不断发展，但是标准化和成功实施对于当今兽医学领域的科学交流仍然至关重要。已经提供了适用于复杂计算的命名法，并已针对功能性基因组学和老化的大规模程序实施。随着人类和兽医病理学的不断发展，大多数术语都在不断发展，但是标准化和成功实施对于当今兽医学领域的科学交流仍然至关重要。已经提供了适用于复杂计算的命名法，并已针对功能性基因组学和老化的大规模程序实施。随着人类和兽医病理学的不断发展，大多数术语都在不断发展，但是标准化和成功实施对于当今兽医学领域的科学交流仍然至关重要。