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Influence of pretreatment quality of life on prognosis in patients with urothelial carcinoma.
International Journal of Clinical Oncology ( IF 3.3 ) Pub Date : 2019-10-26 , DOI: 10.1007/s10147-019-01563-2
Sappaya Suppanuntaroek 1, 2 , Shingo Hatakeyama 1 , Naoki Fujita 1 , Yuka Kubota 1 , Yuichiro Suzuki 1 , Teppei Okamoto 1 , Yuki Tobisawa 1 , Tohru Yoneyama 3 , Hayato Yamamoto 1 , Kazuyuki Mori 1 , Atsushi Imai 1 , Takahiro Yoneyama 3 , Yasuhiro Hashimoto 1 , Chikara Ohyama 1
Affiliation  

BACKGROUND We investigated the association between the pretreatment quality of life (QOL) and overall survival (OS) in patients with urothelial carcinoma (UC), as the influence of pretreatment QOL on prognosis remains unclear in patients with localized and metastatic UC. METHODS Between June 2013 and May 2019, we retrospectively investigated 205 patients with UC who received radical cystectomy or nephroureterectomy for non-metastatic UC (M0 group) or systemic chemotherapy for metastatic UC (M1 group). Patients answered the European Organization for the Research and Treatment of Cancer Quality-of-Life Questionnaire C30 (QLQ-C30) before the treatments. Patients were stratified into two groups: QOL high and low according to the optimal cutoff scores which were defined by receiver operating characteristic curve. Inverse probability of treatment weighting (IPTW)-adjusted multivariate Cox regression analyses were performed to investigate the clinical implication of pretreatment QOL score on OS in patients with UC. RESULTS The number of patients in the M0 and M1 groups was 125 and 80, respectively. Optimal cutoff values in global, fatigue, pain, appetite loss, physical, and role scores were < 50, > 33, > 33, > 16, < 80, and < 67, respectively. IPTW-adjusted multivariate Cox regression analyses revealed that appetite loss score indicated a significantly poorer OS in the M1 group. No significant association of QOL with OS was observed in the M0 group. CONCLUSION Pretreatment QOL of appetite loss may predict poor prognosis of patients with metastatic UC.

中文翻译:

预处理生活质量对尿路上皮癌患者预后的影响。

背景技术我们研究了尿路上皮癌(UC)患者的治疗前生活质量(QOL)与总生存期(OS)之间的关联,因为对于局部和转移性UC患者,治疗前QOL对预后的影响尚不清楚。方法2013年6月至2019年5月,我们回顾性研究了205例行根治性膀胱切除术或肾结石切除术治疗非转移性UC的UC患者(M0组)或进行了转移性UC的全身化疗的患者(M1组)。治疗前,患者回答了欧洲癌症生活质量调查和研究组织C30(QLQ-C30)。根据最佳截止分值将患者分为两组:QOL高分和低分,由接受者工作特征曲线确定。进行了治疗加权比重(IPTW)调整后的多元Cox回归分析,以研究UC患者治疗前QOL评分对OS的临床意义。结果M0和M1组的患者人数分别为125和80。整体,疲劳,疼痛,食欲不振,身体和角色得分的最佳临界值分别为<50,> 33,> 33,> 16,<80和<67。IPTW校正的多元Cox回归分析显示,食欲减退评分表明M1组的OS明显较差。在M0组中未观察到QOL与OS的显着关联。结论食欲减退的治疗前QOL可能预示着转移性UC患者的预后不良。
更新日期:2020-01-30
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