Abstract Translational research using animal models has traditionally involved genetically modified rodents; however, there is increasing use of other novel genetically engineered species. As histology laboratories interface with researchers studying these novel species there will be many situations in which protocols will need to be adapted to the species, model and research goals. This paper gives examples of protocol adaptations to meet research needs and addresses common considerations that should be addressed for all research tissues submitted to the histotechnology laboratory. Positioning the histotechnologist, as well as the investigator, to meet the challenges associated with novel research models will help maximize research efficacy and quality.

中文翻译：

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研究中的转基因物种：组织学核心实验室的机遇和挑战

摘要 使用动物模型的转化研究传统上涉及转基因啮齿动物。然而，越来越多地使用其他新的基因工程物种。当组织学实验室与研究这些新物种的研究人员进行交互时，在许多情况下，协议需要适应物种、模型和研究目标。本文给出了满足研究需求的协议调整示例，并解决了提交给组织技术实验室的所有研究组织应解决的常见注意事项。定位组织技术专家和研究人员，以应对与新型研究模型相关的挑战，将有助于最大限度地提高研究效率和质量。