Vaccines represent one of the greatest triumphs of modern medicine. Despite the common origins of vaccinology and immunology more than 200 years ago, the two disciplines have evolved along such different trajectories that most of the highly successful vaccines have been made empirically, with little or no immunological insight. Recent advances in innate immunity have offered new insights about the mechanisms of vaccine-induced immunity and have facilitated a more rational approach to vaccine design. Here we will discuss these advances and emerging themes on the immunology of vaccination.

中文翻译：

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疫苗接种的免疫学机制。

疫苗代表了现代医学最伟大的胜利之一。尽管疫苗学和免疫学在 200 多年前有着共同的起源，但这两个学科的发展轨迹是如此不同，以至于大多数非常成功的疫苗都是凭经验制造的，几乎没有或根本没有免疫学洞察力。先天免疫的最新进展为疫苗诱导免疫的机制提供了新的见解，并促进了更合理的疫苗设计方法。在这里，我们将讨论疫苗免疫学的这些进展和新出现的主题。