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Natural killer cell memory.
Nature Immunology ( IF 30.5 ) Pub Date : 2011-06-01 , DOI: 10.1038/ni.2032
Silke Paust 1 , Ulrich H von Andrian
Affiliation  

Natural killer (NK) cells are bone marrow–derived granular lymphocytes that have a key role in immune defense against viral and bacterial infections and malignancies. NK cells are traditionally defined as cells of the innate immune response because they lack RAG recombinase–dependent clonal antigen receptors. However, evidence suggests that specific subsets of mouse NK cells can nevertheless develop long-lived and highly specific memory to a variety of antigens. Here we review published evidence of NK cell–mediated, RAG-independent adaptive immunity. We also compare and contrast candidate mechanisms for mammalian NK cell memory and antigen recognition with other examples of RAG-independent pathways that generate antigen receptor diversity in non-mammalian species and discuss NK cell memory in the context of lymphocyte evolution.

中文翻译:

自然杀伤细胞记忆。

自然杀伤 (NK) 细胞是骨髓来源的颗粒淋巴细胞,在针对病毒和细菌感染和恶性肿瘤的免疫防御中起关键作用。NK 细胞传统上被定义为先天免疫反应细胞,因为它们缺乏 RAG 重组酶依赖性克隆抗原受体。然而,有证据表明,小鼠 NK 细胞的特定亚群仍然可以对各种抗原产生长期且高度特异性的记忆。在这里,我们回顾了已发表的 NK 细胞介导的、不依赖 RAG 的适应性免疫的证据。我们还将哺乳动物 NK 细胞记忆和抗原识别的候选机制与在非哺乳动物物种中产生抗原受体多样性的 RAG 独立途径的其他例子进行比较和对比,并在淋巴细胞进化的背景下讨论 NK 细胞记忆。
更新日期:2019-11-01
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