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Regional and mucosal memory T cells.
Nature Immunology ( IF 30.5 ) Pub Date : 2011-06-01 , DOI: 10.1038/ni.2029
Brian S Sheridan 1 , Leo Lefrançois
Affiliation  

After infection, most antigen-specific memory T cells reside in nonlymphoid tissues. Tissue-specific programming during priming leads to directed migration of T cells to the appropriate tissue, which promotes the development of tissue-resident memory in organs such as intestinal mucosa and skin. Mechanisms that regulate the retention of tissue-resident memory T cells include transforming growth factor-β (TGF-β)-mediated induction of the E-cadherin receptor CD103 and downregulation of the chemokine receptor CCR7. These pathways enhance protection in internal organs, such as the nervous system, and in the barrier tissues--the mucosa and skin. Memory T cells that reside at these surfaces provide a first line of defense against subsequent infection, and defining the factors that regulate their development is critical to understanding organ-based immunity.

中文翻译:

区域和粘膜记忆 T 细胞。

感染后,大多数抗原特异性记忆 T 细胞存在于非淋巴组织中。启动期间的组织特异性编程导致 T 细胞定向迁移到适当的组织,从而促进肠粘膜和皮肤等器官中组织驻留记忆的发展。调节组织驻留记忆 T 细胞保留的机制包括转化生长因子-β (TGF-β) 介导的 E-钙粘蛋白受体 CD103 的诱导和趋化因子受体 CCR7 的下调。这些通路增强了对内脏器官(如神经系统)和屏障组织(粘膜和皮肤)的保护。位于这些表面的记忆 T 细胞提供了抵御随后感染的第一道防线,
更新日期:2019-11-01
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