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Optofluidic waveguides: I. Concepts and implementations.
Microfluidics and Nanofluidics ( IF 2.8 ) Pub Date : 2008-01-01 , DOI: 10.1007/s10404-007-0199-7
Holger Schmidt 1 , Aaron R Hawkins
Affiliation  

We review recent developments and current status of liquid-core optical waveguides in optofluidics with emphasis on suitability for creating fully planar optofluidic labs-on-a-chip. In this first of two contributions, we give an overview of the different waveguide types that are being considered for effectively combining micro and nanofluidics with integrated optics. The large number of approaches is separated into conventional index-guided waveguides and more recent implementations using wave interference. The underlying principle for waveguiding and the current status are described for each type. We then focus on reviewing recent work on microfabricated liquid-core antiresonant reflecting optical (ARROW) waveguides, including the development of intersecting 2D waveguide networks and optical fluorescence and Raman detection with planar beam geometry. Single molecule detection capability and addition of electrical control for electrokinetic manipulation and analysis of single bioparticles are demonstrated. The demonstrated performance of liquid-core ARROWs is representative of the potential of integrated waveguides for on-chip detection with ultrahigh sensitivity, and points the way towards the next generation of high-performance, low-cost and portable biomedical instruments.

中文翻译:

光流体波导:I. 概念和实现。

我们回顾了光流体中液芯光波导的最新发展和现状,重点是创建全平面光流体芯片实验室的适用性。在这两个贡献的第一个中,我们概述了正在考虑将微流体和纳米流体与集成光学有效结合的不同波导类型。大量方法分为传统的折射率引导波导和最近使用波干涉的实现。每种类型都描述了波导的基本原理和当前状态。然后,我们重点回顾了最近在微制造液芯反谐振反射光学 (ARROW) 波导方面的工作,包括开发交叉二维波导网络和光学荧光以及平面光束几何形状的拉曼检测。展示了单分子检测能力和添加用于电动操作和分析单个生物颗粒的电气控制。液芯 ARROW 所展示的性能代表了集成波导在具有超高灵敏度的片上检测方面的潜力,并为下一代高性能、低成本和便携式生物医学仪器指明了道路。
更新日期:2019-11-01
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