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A multiscale model of the organ of Corti
Journal of Mechanics of Materials and Structures ( IF 0.9 ) Pub Date : 2009-06-01 , DOI: 10.2140/jomms.2009.4.755
Charles R Steele 1 , Jacques Boutet de Monvel , Sunil Puria
Affiliation  

The organ of Corti is the sensory epithelium in the cochlea of the inner ear. It is modeled as a shell-of-revolution structure with continuous and discrete components. Our recent work has been on the inclusion of the viscous fluid. Measurements from various laboratories provide the opportunity to refocus on the elastic properties. The current detailed model for the organ of Corti is reasonably consistent with diverse measurements. Most components have little stiffness in the propagation direction. However, the isotropic stiffness of the pillar heads is found to offer an explanation for the difference in point load and pressure measurements. The individual rows of inner hair cell stereocilia with tip links and the Hensen stripe are included, since these details are important for the determination of the neural excitation. The results for low frequency show a phase of tip link tension similar to auditory nerve measurements. The nonlinearity of fluid in the small gaps is considered. A result is that as amplitude increases, because of the near contact with the Hensen stripe, the excitation changes polarity, similar to the peak-splitting neural behavior sometimes observed.

中文翻译:

Corti 器官的多尺度模型

Corti 器官是内耳耳蜗中的感觉上皮。它被建模为具有连续和离散分量的旋转壳结构。我们最近的工作是包含粘性流体。来自不同实验室的测量提供了重新关注弹性特性的机会。Corti 器官的当前详细模型与各种测量结果相当一致。大多数组件在传播方向上几乎没有刚度。然而,发现柱头的各向同性刚度可以解释点载荷和压力测量值的差异。带有尖端链接和 Hensen 条纹的内毛细胞静纤毛的各个行都包括在内,因为这些细节对于确定神经兴奋很重要。低频的结果显示了类似于听觉神经测量的尖端链接张力相位。考虑了小间隙中流体的非线性。结果是随着振幅增加,由于与亨森条纹的接近接触,激发改变极性,类似于有时观察到的峰值分裂神经行为。
更新日期:2009-06-01
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