In order to detect diseases like cancer at an early stage while it still may be curable, it's necessary to develop a diagnostic technique which can rapidly and inexpensively detect protein and nucleic acid biomarkers, without making any sacrifice in the sensitivity. We have developed a technique, based on the use of bioactivated microfluidic channels integrated with electrodes for electrical sensing, which can be used to detect protein biomarkers, target cells, and DNA hybridization. In this paper, we discuss the theoretical detection limits of this kind of sensor, and also discuss various experimental considerations in the electrical characterization of our device. In particular, we discuss the temperature dependence, the impedance drift, the noise sources, and various methods for optimizing the signal to noise ratio.

中文翻译：

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使用生物活化微流体通道对蛋白质和 DNA 进行电检测：理论和实验考虑。

为了在早期发现癌症等疾病，同时它仍然可以治愈，有必要开发一种诊断技术，该技术可以快速且廉价地检测蛋白质和核酸生物标志物，而不会牺牲任何灵敏度。我们开发了一种技术，基于使用与电极集成的生物活化微流体通道进行电传感，可用于检测蛋白质生物标志物、靶细胞和 DNA 杂交。在本文中，我们讨论了这种传感器的理论检测极限，还讨论了我们设备的电气特性中的各种实验考虑因素。我们特别讨论了温度相关性、阻抗漂移、噪声源以及优化信噪比的各种方法。