Self-assembled materials composed of beta-sheet forming peptides hold promise as therapeutics and novel biomaterials. This article focuses on the design and engineering of amphiphilic peptide sequences, especially beta-hairpins. Peptides can be designed to intramolecularly fold and then self-assemble on cue, affording hydrogels rich in beta-sheet structure. Hydrogels having distinct material properties can be designed at the molecular level by modulating either the peptide's sequence or the environmental stimulus used to trigger folding and assembly, leading to gelation.

中文翻译：

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用于材料构建的 β-发夹肽的分子设计。

由β-折叠形成肽组成的自组装材料有望作为治疗剂和新型生物材料。本文重点介绍两亲性肽序列的设计和工程，尤其是 β-发夹。肽可以设计为分子内折叠，然后根据提示自组装，提供富含β-折叠结构的水凝胶。通过调节肽的序列或用于触发折叠和组装的环境刺激，从而导致凝胶化，可以在分子水平上设计具有不同材料特性的水凝胶。