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IL-15Rα membrane-anchorage either in cis or in trans is required for stabilization of IL-15 and optimal signaling.
Journal of Cell Science ( IF 4 ) Pub Date : null , DOI: 10.1242/jcs.236802
Agnès Quéméner 1, 2 , Sébastien Morisseau 1, 2, 3 , Rui P Sousa 1, 2, 4 , Kilian Trillet 1, 2 , Mike Maillasson 1, 2, 5 , Isabelle Leray 1, 2 , Yannick Jacques 1, 2 , Johann Dion 5 , Isabelle Barbieux 1, 2 , Marie Frutoso 1, 2 , Adèle D Laurent 4 , Jean-Yves Le Questel 4 , Erwan Mortier 2, 5, 6
Affiliation  

Interleukin(IL)-15 plays an important role in the communication between immune cells. IL-15 delivers its signal through different modes involving three receptor chains: IL-15Rα, IL-2Rβ and γc. The combination of the different chains result in the formation of IL-15Rα/IL-2Rβ/γc trimeric or IL-2Rβ/γc dimeric receptors. In this study, we aimed at investigating the role of IL-15Rα chain in stabilizing the cytokine in the IL-2Rβ/γc dimeric receptor. By analyzing the key residues of IL-15 facing IL-2Rβ, we provided evidence of differential interfaces in the presence or in the absence of membrane-anchored IL-15Rα. Moreover, we found that the anchorage of IL-15Rα to the cell surface regardless its mode of presentation, in cis or in trans, is crucial for complete signaling. These observations show how the cells can finely modulate the intensity of cytokine signaling through the quality and the level of expression of the receptor chains.

中文翻译:

为了稳定IL-15和最佳信号传导,需要顺式或反式IL-15Rα膜锚定。

白介素(IL)-15在免疫细胞之间的通讯中起重要作用。IL-15通过涉及三种受体链的不同模式传递信号:IL-15Rα,IL-2Rβ和γc。不同链的组合导致形成IL-15Rα/IL-2Rβ/γc三聚体或IL-2Rβ/γc二聚体受体。在这项研究中,我们旨在研究IL-15Rα链在稳定IL-2Rβ/γc二聚体受体中细胞因子中的作用。通过分析面对IL-2Rβ的IL-15的关键残基,我们提供了存在或不存在膜锚定IL-15Rα的不同界面的证据。此外,我们发现IL-15Rα在细胞表面的锚定,无论其呈递方式是顺式还是反式,对于完整的信号传导都是至关重要的。
更新日期:2020-03-16
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