Purpose: 

The 10/66 dementia research group (DRG) diagnostic tool was devised to diagnose dementia in people with low education in low and middle-income countries. This study aimed to validate the 10/66 DRG tool in Urdu in Pakistan.

Methodology: 

People older than or equal to 60 years were included: (1) With normal cognition: no/low education, high education, and depression; (2) People with mild and moderate dementia. The diagnostic and statistical manual IV-TR clinician diagnosis was used as the gold standard for dementia. The Clinician Dementia Rating scale was used to rate dementia severity. The geriatric mental status AGECAT stage I output was used to diagnose depression. The 10/66 battery was comprised of CSI-D (cognitive screening instrument for dementia), CERAD (consortium to establish a registry of Alzheimer disease), and animal naming test.

Result: 

The sensitivity and specificity of CSI-D COG score for diagnosing dementia was 86.7% and 72.1%, for CSI-D DF score was 71.1% and 96.1%, for CERAD-10 word list delayed recall was 85.9% and 62.2% at a cut point of ≥5 words, and 70.3% and 97.7% for 10/66 diagnostic algorithm.

Conclusions: 

The 10/66 DRG tool is a valid instrument for diagnosing dementia in the Urdu-speaking population, including with low education and depression, in Pakistan.

中文翻译：

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巴基斯坦卡拉奇乌尔都语10/66痴呆症诊断电池的翻译和验证。

目的： 

在10/66 痴呆研究组（DRG）的诊断工具被设计来诊断老年痴呆症的人在低收入和中等收入国家的教育程度低。本研究旨在验证10/66在DRG工具乌尔都语在巴基斯坦。

方法： 

年龄在60岁或以上的人包括在内：（1）具有正常认知：无/低学历，高等教育和抑郁；（2）轻度和中度痴呆的人。诊断和统计手册IV-TR临床医生的诊断被用作痴呆症的金标准。使用临床痴呆症评分量表对痴呆症严重程度进行评分。老年心理状态AGECAT I期输出用于诊断抑郁症。的10/66电池由CSI-d（认知筛选仪的痴呆），CERAD（财团建立阿尔茨海默病的注册表），和动物命名测试。

结果： 

CSI-D COG评分诊断痴呆的敏感性和特异性分别为86.7％和72.1％，CSI-D DF评分分别为71.1％和96.1％，CERAD-10单词表延迟切开记忆率为85.9％和62.2％ ≥5个单词的点，对于10/66诊断算法为70.3％和97.7％。

结论： 

在10/66 DRG工具是用于诊断有效的工具老年痴呆症在乌尔都语-speaking人口，包括教育程度低和抑郁症，在巴基斯坦。