OBJECTIVE The purpose of our study was to determine the role of brown adipose tissue (BAT) in cancer progression. MATERIALS AND METHODS Our study was approved by our institutional review board and Health Insurance Portability and Accountability Act-compliant. Our study group comprised 132 cancer patients (116 f, 16 m; mean age 50 ± 16 years) who underwent F18-FDG PET/CT per standard clinical protocol, for staging or surveillance of cancer. We included patients who were BAT-positive on PET/CT and had clinical follow-up data available for at least 12 months or until tumor recurrence or tumor-related death, whichever occurred first. BAT volume by PET/CT was quantified by PET-CT Viewer shareware. Clinical information including tumor type, tumor recurrence, survival, and outside temperature at time of scan were recorded. Cox proportional hazard models were used to determine longitudinal associations between BAT volume and tumor recurrence/mortality. RESULTS There were 55 tumor recurrences/tumor-related deaths over a median follow-up period of 71 (33; 110 interquartile range) months. Higher BAT volume was associated with an increased likelihood of tumor recurrence/tumor-associated mortality after adjustment for covariates (p = 0.03). CONCLUSION BAT volume, assessed using routine PET/CT, is a predictor of tumor recurrence/mortality in patients with cancer, independent of other factors that can influence BAT activity, such as sex, age, BMI, or tumor type.

中文翻译：

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棕色脂肪组织和癌症进展。

目的我们研究的目的是确定棕色脂肪组织（BAT）在癌症进展中的作用。材料与方法我们的研究获得了机构审查委员会的批准，并且符合《健康保险携带与责任法案》的要求。我们的研究小组包括132名癌症患者（116 f，16 m；平均年龄50±16岁），他们按照标准临床方案进行了F18-FDG PET / CT，以分期或监测癌症。我们纳入了PET / CT上BAT阳性且具有至少12个月或直到肿瘤复发或肿瘤相关死亡的临床随访数据的患者，以先发生者为准。PET / CT的BAT量通过PET-CT Viewer共享软件进行定量。记录临床信息，包括肿瘤类型，肿瘤复发，生存率和扫描时的外界温度。使用Cox比例风险模型确定BAT量与肿瘤复发/死亡率之间的纵向关联。结果在中位随访期为71（33；四分位间距为110）个月内，有55例肿瘤复发/与肿瘤相关的死亡。调整协变量后，较高的BAT量与肿瘤复发/与肿瘤相关的死亡率增加的可能性相关（p = 0.03）。结论使用常规PET / CT评估的BAT量是癌症患者肿瘤复发/死亡的预测指标，与其他可能影响BAT活性的因素（例如性别，年龄，BMI或肿瘤类型）无关。110个四分位间距范围）个月。调整协变量后，较高的BAT量与肿瘤复发/与肿瘤相关的死亡率增加的可能性相关（p = 0.03）。结论使用常规PET / CT评估的BAT量是癌症患者肿瘤复发/死亡的预测指标，与其他可能影响BAT活性的因素（例如性别，年龄，BMI或肿瘤类型）无关。110个四分位间距范围）个月。调整协变量后，较高的BAT量与肿瘤复发/与肿瘤相关的死亡率增加的可能性相关（p = 0.03）。结论使用常规PET / CT评估的BAT量是癌症患者肿瘤复发/死亡的预测指标，与其他可能影响BAT活性的因素（例如性别，年龄，BMI或肿瘤类型）无关。