Background: The treatment of multiple-drug-resistant tuberculosis (MDR-TB) with currently available marketed drugs remains a global health concern. The cases of resistant tuberculosis patients are increasing day by day.

Objective: The objective of this study is to highlight the need of developing shorter, simpler and tolerable drug regimens.

Methods: In the present study, we synthesized various halo-substituted 2-aryloxyacetohydrazones via a series of reactions from halo-substituted phenols. All the compounds were characterized by using various spectroscopic methods, such as NMR, FT-IR, UV spectroscopy, etc.

Results: All the synthesized hydrazones showed theoretically good interactions with enzyme enoyl reductase (pdb id: 4tzk). All the synthesized compounds (5a-5o) showed moderate to good activity (3.125-100 μg/mL) against Mycobacteria tuberculosis, H37RV strain.

Conclusion: Our results would pave a new way for the development of more effective Anti-TB agents in the future.

背景：用目前可用的市售药物治疗耐多药结核病 (MDR-TB) 仍然是一个全球性的健康问题。耐药结核病患者的病例日益增多。

目的：本研究的目的是强调开发更短、更简单和可耐受的药物治疗方案的必要性。

方法：在本研究中，我们通过卤代苯酚的一系列反应合成了各种卤代 2-芳氧基乙酰腙。所有化合物均采用核磁共振、傅里叶变换红外光谱、紫外光谱等多种光谱方法进行表征。

结果：所有合成的腙在理论上都显示出与酶烯酰还原酶（pdb id：4tzk）良好的相互作用。所有合成的化合物 (5a-5o) 对结核分枝杆菌 H37RV 菌株均表现出中等至良好的活性 (3.125-100 μg/mL)。

结论：我们的研究结果将为未来开发更有效的抗结核药物铺平道路。