Malaria remains a major public health threat in tropical and subtropical regions across the world. Even though less than 1% of malaria infections are fatal, this leads to about 430,000 deaths per year, predominantly in young children in sub-Saharan Africa. Therefore, it is imperative to understand why a subset of infected individuals develop severe syndromes and some of them die and what differentiates these cases from the majority that recovers. Here, we discuss progress made during the past decade in our understanding of malaria pathogenesis, focusing on the major human parasite Plasmodium falciparum.

中文翻译：

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疟疾发病机制的新见解。

疟疾仍然是全球热带和亚热带地区的主要公共卫生威胁。即使不到1％的疟疾感染是致命的，但这仍导致每年约430,000例死亡，主要是撒哈拉以南非洲的幼儿死亡。因此，当务之急是要理解为什么一部分感染者会发展成严重的综合症而其中一些死亡，以及这些病与大多数康复者之间有何区别。在这里，我们将讨论过去十年在对疟疾发病机理的理解上所取得的进展，重点是主要的人类寄生虫恶性疟原虫。