Primate studies indicate that the pyramidal tract (PyT) could originate from Brodmann area (BA) 6. However, in humans, the accurate origin of PyT from BA 6 is still uncertain owing to difficulties in visualizing anatomical features such as the fanning shape at the corona radiata and multiple crossings at the semioval centrum. High angular-resolution diffusion imaging (HARDI) could reliably replicate these anatomical features. We explored the origin of the human PyT from BA 6 using HARDI. With HARDI data of 30 adults from the Massachusetts General Hospital-Human Connectome Project (MGH-HCP) database and the HCP 1021 template (average of 1021 HCP diffusion data), we visualized the PyT at the 30-averaged group level and the 1021 large-sample level and validated the observations in each of the individuals. Endpoints of the fibers within each subregion were quantified. PyT fibers originating from the BA 6 were consistently visualized in all images. Specifically, the bilateral supplementary motor area (SMA) and dorsal premotor area (dPMA) were consistently found to contribute to the PyT. PyT fibers from BA 6 and those from BA 4 exhibited a twisting topology. The PyT contains fibers originating from the SMA and dPMA in BA 6. Infarction of these regions or aging would result in incomplete provision of information to the PyT and concomitant decreases in motor planning and coordination abilities.

中文翻译：

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布罗德曼6区到人的锥体束的投影：使用高角度分辨率数据的定量。

灵长类动物的研究表明，锥体束（PyT）可能起源于Brodmann区域（BA）6。但是，由于难以可视化解剖特征（例如扇形呈扇形），BA 6的PyT的准确起源仍然不确定。放射状电晕和在半卵形中心的多个交叉点。高角分辨率扩散成像（HARDI）可以可靠地复制这些解剖特征。我们使用HARDI探索了BA 6中人PyT的起源。借助马萨诸塞州总医院-人类连接基因组计划（MGH-HCP）数据库中的30名成年人的HARDI数据和HCP 1021模板（1021 HCP扩散数据的平均值），我们在30个平均组水平和1021个大水平上显示了PyT样本水平，并验证每个人的观察结果。量化每个子区域内纤维的端点。在所有图像中始终可见来自BA 6的PyT纤维。具体而言，始终发现双侧辅助运动区（SMA）和背运动前区（dPMA）有助于PyT。来自BA 6和来自BA 4的PyT纤维表现出加捻拓扑。PyT包含来自BA 6中SMA和dPMA的纤维。这些区域的梗塞或老化将导致无法向PyT提供信息，并且随之而来的是运动计划和协调能力下降。来自BA 6和来自BA 4的PyT纤维表现出加捻拓扑。PyT包含源自BA 6中SMA和dPMA的纤维。这些区域的梗塞或老化会导致无法完全向PyT提供信息，并随之导致运动计划和协调能力下降。来自BA 6和来自BA 4的PyT纤维表现出加捻拓扑。PyT包含来自BA 6中SMA和dPMA的纤维。这些区域的梗塞或老化将导致无法向PyT提供信息，并且随之而来的是运动计划和协调能力下降。