Meat quality has an inherent complexity because of the multiple interrelated causative factors and layers of feedback regulation. Understanding the key factors and their interactions has been challenging, despite the availability of remarkable high-throughput tools and techniques that have provided insights on muscle metabolism and the genetic basis of meat quality. Likewise, we have deepened our knowledge about mineral metabolism and its role in cell functioning. Regardless of these facts, complex traits like mineral content and meat quality have been studied under reductionist approaches. However, as these phenotypes arise from complex interactions among different biological layers (genome, transcriptome, proteome, epigenome, etc.), along with environmental effects, a holistic view and systemic-level understanding of the genetic basis of complex phenotypes are in demand. Based on the state of the art, we addressed some of the questions regarding the interdependence of meat quality traits and mineral content. Furthermore, we sought to highlight potential regulatory mechanisms arising from the genes, miRNAs, and mineral interactions, as well as the pathways modulated by this interplay affecting muscle, mineral metabolism, and meat quality. By answering these questions, we did not intend to give an exhaustive review but to identify the key biological points, the challenges, and benefits of integrative genomic approaches.

中文翻译：

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矿物质代谢与肉质之间的相互影响：系统生物学概述。

肉质具有内在的复杂性，这是因为存在多个相互关联的原因因素和反馈调节层。尽管可以使用重要的高通量工具和技术，但对肌肉代谢和肉质品质的遗传基础提供了见识，但了解关键因素及其相互作用仍然是一项挑战。同样，我们加深了对矿物质代谢及其在细胞功能中作用的认识。无论这些事实如何，都已通过还原论方法研究了诸如矿物质含量和肉品质等复杂特征。但是，由于这些表型是由不同生物层（基因组，转录组，蛋白质组，表观基因组等）之间复杂的相互作用引起的，以及环境影响，需要对复杂表型的遗传基础有一个整体的看法和系统的理解。基于最先进的技术，我们解决了一些有关肉质性状和矿物质含量相互依存的问题。此外，我们试图强调由基因，miRNA和矿物质相互作用产生的潜在调控机制，以及由这种相互作用所调节的影响肌肉，矿物质代谢和肉质的途径。通过回答这些问题，我们无意进行详尽的综述，而是要确定整合基因组学方法的关键生物学点，挑战和好处。我们试图强调由基因，miRNA和矿物质相互作用产生的潜在调控机制，以及由这种相互作用所调节的影响肌肉，矿物质代谢和肉质的途径。通过回答这些问题，我们无意进行详尽的综述，而是要确定整合基因组学方法的关键生物学点，挑战和好处。我们试图强调由基因，miRNA和矿物质相互作用产生的潜在调控机制，以及由这种相互作用所调节的影响肌肉，矿物质代谢和肉质的途径。通过回答这些问题，我们无意进行详尽的综述，而是要确定整合基因组学方法的关键生物学点，挑战和好处。