Hepcidin, a peptide hormone produced by the liver, constitutes the master regulator of iron homeostasis in mammals allowing iron adaptation according to the body iron needs. In recent years there has been important breakthrough in our knowledge of hepcidin regulation that has also implications for understanding the physiopathology of human iron disorders. Different aspects of hepcidin regulation will be considered in this review, including regulation by the iron status and the BMP6/HJV/SMAD pathway. Hepcidin dysregulation in iron disorders will be also discussed. Although much can already be accomplished for treating iron disorders using the knowledge that has currently been developed, additional issues will be challenging for the coming years.

中文翻译：

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铁警钟铁兵。

铁调素是由肝脏产生的一种肽激素，是哺乳动物体内铁稳态的主要调节剂，可根据人体铁的需要进行铁的适应。近年来，我们对铁调素调节的认识取得了重要突破，这对理解人类铁疾病的生理病理学也具有重要意义。本文将考虑铁调素调节的不同方面，包括铁状态和BMP6 / HJV / SMAD途径的调节。铁障碍中的铁调素也将被讨论。尽管利用目前已掌握的知识已经可以在治疗铁质疾病方面取得许多成就，但在未来几年中，其他问题将面临挑战。