Qihong Que and colleagues found that liraglutide exhibited anti-inflammatory activity through the activation of the PKA/CREB pathway in an OA rat model. We believe there was a flaw in this research. In their first experiment, the sacrifice time of the 10 rats in the control group has not been stated. And when the rats in the OA-1, OA-5, OA-10, OA-20 and OA-28 groups were sacrificed, they were in different weeks of age. If the rats in the control group were compared to the rats in the OA-1, OA-5, OA-10, OA-20 and OA-28 groups respectively, the results may be biased due to differences in the week age of the rats. We believe that addressing this issue could further increase the value of their study.

中文翻译：

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利拉鲁肽通过激活PKA / CREB途径表现出抗炎活性。

Qihong Que及其同事发现，利拉鲁肽在OA大鼠模型中通过激活PKA / CREB途径表现出抗炎活性。我们认为这项研究存在缺陷。在他们的第一个实验中，对照组中的10只大鼠的牺牲时间尚未阐明。并且当处死OA-1，OA-5，OA-10，OA-20和OA-28组的大鼠时，它们处于不同的周龄。如果将对照组中的大鼠分别与OA-1，OA-5，OA-10，OA-20和OA-28组中的大鼠进行比较，则结果可能会有所不同，因为它们的周龄不同大鼠。我们认为解决这个问题可能会进一步增加他们的研究价值。