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Role and regulation of the stress activated sigma factor sigma B (σB) in the saprophytic and host-associated life stages of Listeria monocytogenes.
Advances in Applied Microbiology ( IF 5.515 ) Pub Date : 2018-12-24 , DOI: 10.1016/bs.aambs.2018.11.001
Amber Dorey 1 , Catarina Marinho 1 , Pascal Piveteau 2 , Conor O'Byrne 1
Affiliation  

The stress activated sigma factor sigma B (σB) plays a pivotal role in allowing the food-borne bacterial pathogen Listeria monocytogenes to modulate its transcriptional landscape in order to survive in a variety of harsh environments both outside and within the host. While we have a comparatively good understanding of the systems under the control of this sigma factor much less is known about how the activity of σB is controlled. In this review, we present a current model describing how this sigma factor is thought to be controlled including an overview of what is known about stress sensing and the early signal transduction events that trigger its activation. We discuss the known regulatory overlaps between σB and other protein and RNA regulators in the cell. Finally, we describe the role of σB in surviving both saprophytic and host-associated stresses. The complexity of the regulation of this sigma factor reflects the significant role that it plays in the persistence of this important pathogen in the natural environment, the food chain as well as within the host during the early stages of an infection. Understanding its regulation will be a critical step in helping to develop rational strategies to prevent its growth and survival in the food destined for human consumption and in the prevention of listeriosis.



中文翻译:

单核细胞增生性李斯特菌的腐生和寄主相关生命阶段中,应力激活的sigma因子sigma B(σB)的作用和调节。

的应激活化σ因子西格玛B(σ)在允许起着关键作用食源性细菌病原体李斯特菌以调节,以便在各种恶劣环境的外部和在宿主内生存其转录景观。虽然我们有这个σ因子的控制下的系统更被知道关于σ的活动是如何的一个比较好理解被控制。在本文中,我们介绍了一种当前模型,该模型描述了如何认为该sigma因子受到控制,包括有关应力感测和触发其激活的早期信号转导事件的概述。我们讨论σ之间的已知监管上的重叠以及细胞中的其他蛋白质和RNA调节剂。最后,我们描述σ的作用存活都腐生和主机相关的应力。此sigma因子调控的复杂性反映了它在感染初期在自然环境,食物链以及宿主体内这种重要病原体的持久性中发挥的重要作用。理解其调控将是帮助制定合理策略以防止其在预定供人类食用的食物中生长和存活以及预防李斯特菌病的关键步骤。

更新日期:2018-12-24
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