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γδ T cells in cancer: a small population of lymphocytes with big implications.
Clinical & Translational Immunology ( IF 5.8 ) Pub Date : 2019-10-19 , DOI: 10.1002/cti2.1080
Mathilde Raverdeau 1 , Stephen P Cunningham 1 , Cathal Harmon 2, 3 , Lydia Lynch 1, 2, 3
Affiliation  

γδ T cells are a small population of mostly tissue-resident lymphocytes, with both innate and adaptive properties. These unique features make them particularly attractive candidates for the development of new cellular therapy targeted against tumor development. Nevertheless, γδ T cells may play dual roles in cancer, promoting cancer development on the one hand, while participating in antitumor immunity on the other hand. In mice, γδ T-cell subsets preferentially produce IL-17 or IFN-γ. While antitumor functions of murine γδ T cells can be attributed to IFN-γ+ γδ T cells, recent studies have implicated IL-17+ γδ T cells in tumor growth and metastasis. However, in humans, IL-17-producing γδ T cells are rare and most studies have attributed a protective role to γδ T cells against cancer. In this review, we will present the current knowledge and most recent findings on γδ T-cell functions in mouse models of tumor development and human cancers. We will also discuss their potential as cellular immunotherapy against cancer.

中文翻译:

癌症中的γδT细胞:一小群淋巴细胞,意义重大。

γδT细胞是一小部分主要是组织驻留淋巴细胞,具有先天和适应特性。这些独特的功能使它们成为针对肿瘤发展的新细胞疗法发展的特别有吸引力的候选者。然而,γδT细胞可能在癌症中起双重作用,一方面促进癌症发展,另一方面又参与抗肿瘤免疫。在小鼠中,γδT细胞亚群优先产生IL-17或IFN-γ。虽然鼠γδT细胞的抗肿瘤功能可以归因于IFN-γ+γδT细胞,但最近的研究表明IL-17 +γδT细胞参与了肿瘤的生长和转移。但是,在人类中,产生IL-17的γδT细胞很少见,大多数研究都将其归因于γδT细胞具有抗癌作用。在这篇评论中 我们将介绍肿瘤发展和人类癌症的小鼠模型中γδT细胞功能的最新知识和最新发现。我们还将讨论它们作为抗癌细胞免疫疗法的潜力。
更新日期:2019-11-01
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