Aim Iron overload is a life-threatening disorder that can increase the risks of cancer, cardiovascular disease, and liver cirrhosis. There is also a risk of iron overload in patients with chronic kidney disease. In patients with renal failure, iron storage is increased due to inadequate iron utilization associated with decreased erythropoiesis and also to the inflammatory status. To evade the risk of iron overload, an accurate and versatile indicator of body iron storage in patients with iron overload is needed. In this study, we aimed to find useful iron-related parameters that could accurately reflect body iron storage in mice in order to construct a murine model of iron overload. Methods To select an appropriate indicator of body iron status, a variety of parameters involved in iron metabolism were evaluated. Noninvasively measured parameters were R1, R2, and R2 ∗ derived from magnetic resonance imaging (MRI). Invasively measured parameters included serum hepcidin levels, serum ferritin levels, and liver iron contents. Histopathological analysis was also conducted. Results/Conclusion Among the several parameters evaluated, the MRI T2 ∗ relaxation time was able to detect iron storage in the liver as sensitively as serum ferritin levels. Moreover, it is expected that using an MRI parameter will allow accurate evaluation of body iron storage in mice over time.

中文翻译：

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从肝脏的磁共振成像获得的T2 *弛豫时间是用于构建铁超负荷小鼠模型的有用参数。

目的铁超载是一种威胁生命的疾病，可增加罹患癌症，心血管疾病和肝硬化的风险。慢性肾脏病患者也有铁超负荷的风险。在肾功能衰竭的患者中，铁的储存量增加是由于铁利用不足，红细胞生成减少以及炎症状态所致。为了规避铁过载的风险，需要一种准确，通用的指示铁过载患者体内铁存储的指标。在这项研究中，我们旨在寻找有用的铁相关参数，以准确反映小鼠体内铁的储藏量，从而构建铁超负荷的小鼠模型。方法为了选择合适的人体铁状况指标，对铁代谢的各种参数进行了评估。非侵入式测量的参数是源自磁共振成像（MRI）的R1，R2和R2 *。有创测量的参数包括血清铁调素水平，血清铁蛋白水平和肝铁含量。还进行了组织病理学分析。结果/结论在评估的几个参数中，MRI T2 *弛豫时间能够像血清铁蛋白水平一样灵敏地检测肝脏中的铁存储。而且，期望使用MRI参数将允许随着时间的推移准确评估小鼠体内铁的储存。MRI T2 *弛豫时间能够像血清铁蛋白水平一样灵敏地检测肝脏中的铁存储。而且，期望使用MRI参数将允许随着时间的推移准确评估小鼠体内铁的储存。MRI T2 *弛豫时间能够像血清铁蛋白水平一样灵敏地检测肝脏中的铁存储。而且，期望使用MRI参数将允许随着时间的推移准确评估小鼠体内铁的储存。