The interleukin (IL)-4, 1,25(OH)2D3 and retinoic acid, increase surface expression of functional integrin αvβ3 on murine osteoclast precursors. All three agonists stimulate transcription of the β3 gene, leading to increased steady-state levels of mRNA this protein. By contrast, mRNA levels of αv remain unchanged. In each instance, the increase in the surface expression of the integrin results in increased migration of the cells onto an αvβ3 substrate. Because β3 subunit, except platelet where β3 subunit conform a dimer with αIIb, associates solely with αv subunit monogamously, while promiscuous αv subunit combines with various subunit, our present data support the idea that the β3 subunit governs the surface-expressed functional integrin complex.

中文翻译：

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1,25（OH）2D3，维甲酸和白介素-4通过激活小鼠骨髓巨噬细胞上的β3整合素基因来激活αvβ3整合素。

白介素（IL）-4、1,25（OH）2D3和视黄酸增加了功能性整联蛋白αvβ3在鼠破骨细胞前体上的表面表达。所有这三种激动剂均刺激β3基因的转录，从而导致该蛋白mRNA的稳态水平提高。相反，αv的mRNA水平保持不变。在每种情况下，整联蛋白表面表达的增加导致细胞向αvβ3底物迁移的增加。因为除了血小板中β3亚基与αIIb符合二聚体的β3亚基外，它仅与αv亚基一夫一妻地缔合，而混杂的αv亚基与各种亚基结合，因此我们目前的数据支持β3亚基支配表面表达的功能整合素复合物的想法。