This work mainly focuses on the graphene oxide (GO)‐assisted sustainable drug delivery of famotidine (FMT) drug. Famotidine is loaded onto GO and encapsulated by chitosan (CH). UV‐visible spectroscopy, field emission scan electron microscopy, and atomic force microscopy confirm the loading of FMT on GO. An interaction of FMT with GO and CH through amine functionalities is confirmed by Fourier‐transform infrared spectroscopy. Differential scanning calorimetric and cyclic voltammetric investigations confirm the compatibility of FMT and its retaining activity within chitosan‐functionalized graphene oxide (CHGO) composite. Encapsulation efficiency of FMT is determined for various CHGO‐FMT combinations and found to be higher at 1:9 ratio. The in vitro drug release profile is studied using a dissolution test apparatus in 0.1 m phosphate buffer medium (pH = 4.5), which shows sustainable drug release up to 12 h, which is greater than the market product (Complete release within 2 h). Comparative study of drug encapsulated with CH and without GO elucidates that GO is responsible for the sustainable release. The “n” value obtained from slope using Korsmeyer–Peppas model suggests the super case‐II transport mechanism.

中文翻译：

---

使用壳聚糖功能化氧化石墨烯作为纳米载体进行法莫替丁的可持续药物输送。

这项工作主要集中在氧化石墨烯（GO）辅助法莫替丁（FMT）药物的可持续给药。法莫替丁负载到 GO 上并被壳聚糖 (CH) 封装。紫外可见光谱、场发射扫描电子显微镜和原子力显微镜证实了 FMT 在 GO 上的负载。傅里叶变换红外光谱证实了 FMT 通过胺官能团与 GO 和 CH 发生相互作用。差示扫描量热和循环伏安研究证实了 FMT 的相容性及其在壳聚糖功能化氧化石墨烯 (CHGO) 复合材料中的保留活性。针对各种 CHGO-FMT 组合测定了 FMT 的封装效率，发现 1:9 的比例时 FMT 的封装效率更高。使用溶出度测试仪在0.1 m磷酸盐缓冲介质（pH = 4.5）中研究体外药物释放曲线，结果显示药物可持续释放长达12小时，这高于市场产品（2小时内完全释放）。用 CH 和不含 GO 封装的药物的比较研究表明，GO 负责可持续释放。使用 Korsmeyer-Peppas 模型从斜率获得的“ n ”值表明了超级案例 II 传输机制。