Introduction. The aim of this prospective study was to investigate excessive daytime sleepiness (EDS) over time and in relation to other PD symptoms among people with Parkinson’s disease (PD). Methods. Thirty participants younger than 65 years with PD were randomly selected. At inclusion, mean (SD) disease duration was 6.2 (4.8) years and median (min-max) severity of PD was classified as stage II (stages I–III) according to Hoehn and Yahr. Participants were followed annually for 10 years with clinical assessments of their PD status, medications, comorbidities, and a standardized interview about their sleep habits and occurrence of daytime sleepiness. EDS was assessed by the self-reported Epworth Sleepiness Scale (ESS). Seventeen participants completed the 10-year longitudinal follow-up. Results. Fifteen of 30 persons were classified to suffer from EDS (ESS > 10) at baseline. At the group level, EDS remained stable over 10 years and did not deteriorate in parallel with worsening of motor symptoms. Furthermore, EDS was associated with sleep quality, fatigue, anxiety, depression, and axial/postural/gait impairments. Conclusions. EDS did not worsen over 10 years, although other PD aspects did. EDS in PD seems to be a complex nonmotor symptom that is unrelated to deterioration of motor symptoms in PD.

中文翻译：

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帕金森病白天过度嗜睡的 10 年随访。

简介。这项前瞻性研究的目的是调查随着时间的推移过度白天嗜睡 (EDS) 以及与帕金森病 (PD) 患者的其他 PD 症状的关系。方法。随机选择了 30 名 65 岁以下的 PD 参与者。纳入时，平均 (SD) 疾病持续时间为 6.2 (4.8) 年，根据 Hoehn 和 Yahr 将 PD 的中位 (min-max) 严重程度分类为 II 期（I-III 期）。参与者每年接受为期 10 年的随访，对他们的 PD 状态、药物、合并症进行临床评估，并对他们的睡眠习惯和白天嗜睡的发生进行标准化访谈。EDS 通过自我报告的 Epworth 嗜睡量表 (ESS) 进行评估。17 名参与者完成了 10 年的纵向随访。结果。30 人中有 15 人在基线时被归类为患有 EDS (ESS > 10)。在组水平上，EDS 在 10 年内保持稳定，并且没有随着运动症状的恶化而恶化。此外，EDS 与睡眠质量、疲劳、焦虑、抑郁和轴向/姿势/步态障碍有关。结论。EDS 在 10 年内没有恶化，尽管其他 PD 方面确实如此。PD 中的 EDS 似乎是一种复杂的非运动症状，与 PD 中运动症状的恶化无关。