当前位置: X-MOL 学术NanoImpact › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Chemical and physical transformations of silver nanomaterial containing textiles after modeled human exposure
NanoImpact ( IF 4.9 ) Pub Date : 2019-02-01 , DOI: 10.1016/j.impact.2019.100160
Danielle E Gorka 1 , Nancy J Lin 1 , John M Pettibone 1 , Justin M Gorham 1
Affiliation  

The antimicrobial properties of silver nanomaterials (AgNM) have been exploited in various consumer applications, including textiles such as wound dressings. Understanding how these materials chemically transform throughout their use is necessary to predict their efficacy during use and their behavior after disposal. The aim of this work was to evaluate chemical and physical transformations to a commercial AgNM-containing wound dressing during modeled human exposure to synthetic sweat (SW) or simulated wound fluid (WF). Scanning electron microscopy with energy dispersive X-ray spectroscopy (EDS) revealed the formation of micrometer-sized structures at the wound dressing surface after SW exposure while WF resulted in a largely featureless surface. Measurements by X-ray photoelectron spectroscopy (XPS) revealed a AgCl surface (consistent with EDS) while X-ray diffraction (XRD) found a mixture of zero valent silver and AgCl suggesting the AgNM wound dressings surface formed a passivating AgCl surface layer after SW and WF exposure. For WF, XPS based findings revealed the addition of an adsorbed protein layer based on the nitrogen marker which adsorbed released silver at prolonged exposures. Silver release was evaluated by inductively coupled plasma mass spectrometry which revealed a significant released silver fraction in WF and minimal released silver in SW. Analysis suggests that the protein in WF sequestered a fraction of the released silver which continued with exposure time, suggesting additional processing at the wound dressing surface even after the initial transformation to AgCl. To evaluate the impact on antimicrobial efficacy, zone of inhibition (ZOI) testing was conducted which found no significant change after modeled human exposure compared to the pristine wound dressing. The results presented here suggest AgNM-containing wound dressings transform chemically in simulated human fluids resulting in a material with comparable antimicrobial properties with pristine wound dressings. Ultimately, knowing the resulting chemical properties of the AgNM wound dressings will allow better predictive models to be developed regarding their fate.

中文翻译:

模拟人体暴露后含银纳米材料的纺织品的化学和物理转变

银纳米材料 (AgNM) 的抗菌特性已被用于各种消费应用,包括纺织品,如伤口敷料。了解这些材料在整个使用过程中如何发生化学变化对于预测它们在使用过程中的功效和处置后的行为是必要的。这项工作的目的是评估在模拟人体暴露于合成汗液 (SW) 或模拟伤口液 (WF) 期间向含有 AgNM 的商业伤口敷料的化学和物理转变。具有能量色散 X 射线光谱 (EDS) 的扫描电子显微镜显示,在 SW 暴露后,伤口敷料表面形成微米级结构,而 WF 导致表面基本无特征。X 射线光电子能谱 (XPS) 测量显示 AgCl 表面(与 EDS 一致),而 X 射线衍射 (XRD) 发现零价银和 AgCl 的混合物表明 AgNM 伤口敷料表面在 SW 后形成钝化 AgCl 表面层和 WF 曝光。对于 WF,基于 XPS 的研究结果揭示了基于氮标记物的吸附蛋白质层的添加,其在长时间暴露时吸附释放的银。通过电感耦合等离子体质谱法评估银释放,其显示 WF 中释放的银分数显着,而 SW 中释放的银最少。分析表明,WF 中的蛋白质螯合了一部分释放的银,随着暴露时间的延长,这表明即使在最初转化为 AgCl 之后,伤口敷料表面也有额外的处理。为了评估对抗菌功效的影响,进行了抑菌圈 (ZOI) 测试,与原始伤口敷料相比,模拟人体暴露后没有发现显着变化。此处显示的结果表明,含 AgNM 的伤口敷料在模拟人体体液中发生化学转化,从而产生具有与原始伤口敷料相当的抗菌性能的材料。最终,了解 AgNM 伤口敷料的化学特性将有助于开发关于其命运的更好预测模型。此处显示的结果表明,含 AgNM 的伤口敷料在模拟人体体液中发生化学转化,从而产生具有与原始伤口敷料相当的抗菌性能的材料。最终,了解 AgNM 伤口敷料的化学特性将有助于开发关于其命运的更好预测模型。此处显示的结果表明,含 AgNM 的伤口敷料在模拟人体体液中发生化学转化,从而产生具有与原始伤口敷料相当的抗菌性能的材料。最终,了解 AgNM 伤口敷料的化学特性将有助于开发关于其命运的更好预测模型。
更新日期:2019-02-01
down
wechat
bug