Correlation of TSHR and CTLA-4 Single Nucleotide Polymorphisms with Graves Disease.,International Journal of Genomics

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Correlation of TSHR and CTLA-4 Single Nucleotide Polymorphisms with Graves Disease.
International Journal of Genomics ( IF 2.9 ) Pub Date : 2019-09-03 , DOI: 10.1155/2019/6982623
Weihua Sun _{1,

2} , Xiaomei Zhang ₂ , Jing Wu ₂ , Wendi Zhao ₂ , Shuangxia Zhao ₃ , Minglong Li ₁

Affiliation

This study was designed to explore the association between Graves disease (GD) and thyroid-stimulating hormone receptor (TSHR) and cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) single nucleotide polymorphisms (SNPs). We studied a total of 1217 subjects from a Han population in northern Anhui province in China. Six SNPs within TSHR (rs179247, rs12101261, rs2284722, rs4903964, rs2300525, and rs17111394) and four SNPs within CTLA-4 (rs10197319, rs231726, rs231804, and rs1024161) were genotyped via a Taqman probe technique using a Fluidigm EP1 platform. The TSHR alleles rs179247-G, rs12101261-C, and rs4903964-G were negatively correlated with GD, whereas the rs2284722-A and rs17111394-C alleles were positively correlated with GD. Analyzing TSHR SNPs at rs179247, rs2284722, rs12101261, and rs4903964 yielded 8 different haplotypes. There were positive correlations between GD risk and the haplotypes AGTA and AATA (, , ; , , , respectively). There were negative correlations between GD risk and the haplotype GGCG (, , ). With respect to haplotypes based on SNPs at the TSHR rs2300525 and rs17111394 loci, the CC haplotype was positively correlated with GD risk (, , ). Analyzing CTLA-4 SNPs at rs231804, rs1024161, and rs231726 yielded four haplotypes, of which AAA was positively correlated with GD risk (, , ). Polymorphisms at rs179247, rs12101261, rs2284722, rs4903964, and rs17111394 were associated with GD susceptibility. Haplotypes of both TSHR and CTLA-4 were additionally related to GD risk.

更新日期：2019-09-03

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