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Assessment of T helper 17-associated cytokines in thromboangiitis obliterans.
Journal of Inflammation Research ( IF 4.5 ) Pub Date : 2019-09-05 , DOI: 10.2147/jir.s218105 Shayan Keramat 1 , Mohammad Hadi Sadeghian 1, 2 , Mohammad Reza Keramati 1, 2 , Bahare Fazeli 3, 4
Journal of Inflammation Research ( IF 4.5 ) Pub Date : 2019-09-05 , DOI: 10.2147/jir.s218105 Shayan Keramat 1 , Mohammad Hadi Sadeghian 1, 2 , Mohammad Reza Keramati 1, 2 , Bahare Fazeli 3, 4
Affiliation
Background: The management of thromboangiitis obliterans (TAO) remains a medical challenge because of its unknown etiology. It is also not known whether it is a systemic or localized disease or a type of autoimmune vasculitis.
Methods: In this study, we evaluated the serum level of IL-17 and IL-23 which increase in both systemic inflammation and autoimmunity, in 60 TAO patients and 30 age- and smoking habit-matched controls. Also, IL-22, which has reported high level during infection but not in autoimmunity, was evaluated.
Results: The serum levels of IL-17, IL-22 and IL-23 were significantly higher in the TAO patients in comparison with the controls (P<0.001). Notably, the serum levels of IL-17, IL-22 and IL-23 were highest in the patients with the chief complaint of chronic ulcer and lowest in the patients with gangrene (P<0.05). Also, the serum level of IL-22 was significantly higher in the anemic patients in comparison with the non-anemic patients (P=0.03).
Conclusion: Owing to our findings, TAO appears more likely to be a systemic disorder rather than a localized vasculopathy. Therefore, treatment protocols based on systemic treatment of TAO patients may be more helpful than localized treatment, such as bypass surgery and endovascular procedures. Also, according to our findings regarding the high level of IL-22, the trigger of TAO development may be an infectious pathogen. However, additional research is highly recommended to investigate whether TAO is an infectious disease or an infectious-induced autoimmunity.
中文翻译：
血栓闭塞性脉管炎中 T 辅助 17 相关细胞因子的评估。
背景：血栓闭塞性脉管炎 (TAO) 的管理仍然是一个医学挑战，因为它的病因不明。也不知道它是全身性疾病还是局部疾病，还是一种自身免疫性血管炎。
方法：在这项研究中，我们评估了 60 名 TAO 患者和 30 名年龄和吸烟习惯匹配的对照者的血清 IL-17 和 IL-23 水平，它们在全身炎症和自身免疫方面均增加。此外，还评估了在感染期间报告高水平但在自身免疫中没有的 IL-22。
结果： TAO患者血清IL-17、IL-22、IL-23水平显着高于对照组（P<0.001)。值得注意的是，主诉慢性溃疡患者血清IL-17、IL-22、IL-23水平最高，坏疽患者血清IL-17、IL-22和IL-23水平最低（P <0.05）。此外，与非贫血患者相比，贫血患者的血清IL-22水平显着高于非贫血患者（P = 0.03）。
结论：由于我们的研究结果，TAO 似乎更可能是一种全身性疾病，而不是局部血管病变。因此，基于 TAO 患者全身治疗的治疗方案可能比局部治疗更有帮助，例如搭桥手术和血管内手术。此外，根据我们关于高水平 IL-22 的发现，TAO 发展的触发因素可能是一种传染性病原体。然而，强烈建议进行额外的研究来调查 TAO 是一种传染病还是一种感染诱导的自身免疫。
更新日期：2019-09-05
Methods: In this study, we evaluated the serum level of IL-17 and IL-23 which increase in both systemic inflammation and autoimmunity, in 60 TAO patients and 30 age- and smoking habit-matched controls. Also, IL-22, which has reported high level during infection but not in autoimmunity, was evaluated.
Results: The serum levels of IL-17, IL-22 and IL-23 were significantly higher in the TAO patients in comparison with the controls (P<0.001). Notably, the serum levels of IL-17, IL-22 and IL-23 were highest in the patients with the chief complaint of chronic ulcer and lowest in the patients with gangrene (P<0.05). Also, the serum level of IL-22 was significantly higher in the anemic patients in comparison with the non-anemic patients (P=0.03).
Conclusion: Owing to our findings, TAO appears more likely to be a systemic disorder rather than a localized vasculopathy. Therefore, treatment protocols based on systemic treatment of TAO patients may be more helpful than localized treatment, such as bypass surgery and endovascular procedures. Also, according to our findings regarding the high level of IL-22, the trigger of TAO development may be an infectious pathogen. However, additional research is highly recommended to investigate whether TAO is an infectious disease or an infectious-induced autoimmunity.
中文翻译：
血栓闭塞性脉管炎中 T 辅助 17 相关细胞因子的评估。
背景：血栓闭塞性脉管炎 (TAO) 的管理仍然是一个医学挑战，因为它的病因不明。也不知道它是全身性疾病还是局部疾病，还是一种自身免疫性血管炎。
方法：在这项研究中，我们评估了 60 名 TAO 患者和 30 名年龄和吸烟习惯匹配的对照者的血清 IL-17 和 IL-23 水平，它们在全身炎症和自身免疫方面均增加。此外，还评估了在感染期间报告高水平但在自身免疫中没有的 IL-22。
结果： TAO患者血清IL-17、IL-22、IL-23水平显着高于对照组（P<0.001)。值得注意的是，主诉慢性溃疡患者血清IL-17、IL-22、IL-23水平最高，坏疽患者血清IL-17、IL-22和IL-23水平最低（P <0.05）。此外，与非贫血患者相比，贫血患者的血清IL-22水平显着高于非贫血患者（P = 0.03）。
结论：由于我们的研究结果，TAO 似乎更可能是一种全身性疾病，而不是局部血管病变。因此，基于 TAO 患者全身治疗的治疗方案可能比局部治疗更有帮助，例如搭桥手术和血管内手术。此外，根据我们关于高水平 IL-22 的发现，TAO 发展的触发因素可能是一种传染性病原体。然而，强烈建议进行额外的研究来调查 TAO 是一种传染病还是一种感染诱导的自身免疫。
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