G protein-coupled receptors (GPCRs) play a pivotal role in the adaptive responses to cellular stresses such as hypoxia. In addition to influencing cellular gene expression profiles, hypoxic microenvironments can perturb membrane protein localization, altering GPCR effector scaffolding and altering downstream signaling. Studies using proteomics approaches have revealed significant regulation of GPCR and G proteins by their state of post-translational modification. The aim of this review is to examine the effects of post-translational modifications on membrane localization and signaling of GPCR-G protein complexes, with an emphasis on vascular prostanoid receptors, and to highlight what is known about the effect of cellular hypoxia on these mechanisms. Understanding post-translational modifications of protein targets will help to define GPCR targets in treatment of disease, and to inform research into mechanisms of hypoxic cellular responses.

中文翻译：

---

翻译后修饰对前列腺素GPCR-G蛋白复合物膜定位和信号传导的影响以及缺氧的作用。

G蛋白偶联受体（GPCR）在对细胞应激（如缺氧）的适应性反应中起关键作用。除影响细胞基因表达谱外，低氧微环境还会干扰膜蛋白的定位，改变GPCR效应子的支架并改变下游的信号传导。使用蛋白质组学方法的研究表明，通过其翻译后修饰状态，GPCR和G蛋白具有明显的调节作用。这篇综述的目的是研究翻译后修饰对膜定位和GPCR-G蛋白复合物信号传导的影响，重点是血管类前列腺素受体，并强调关于细胞低氧对这些机制的影响的已知信息。