Rhodopsin is the light receptor in photoreceptor cells of the retina and a prototypical G protein-coupled receptor. Two types of quaternary structures can be adopted by rhodopsin. If rhodopsin folds and attains a proper tertiary structure, it can then form oligomers and nanodomains within the photoreceptor cell membrane. In contrast, if rhodopsin misfolds, it cannot progress through the biosynthetic pathway and instead will form aggregates that can cause retinal degenerative disease. In this review, emerging views are highlighted on the supramolecular organization of rhodopsin within the membrane of photoreceptor cells and the aggregation of rhodopsin that can lead to retinal degeneration.

中文翻译：

---

视紫红质的低聚和聚集。

视紫红质是视网膜感光细胞中的光受体，是原型G蛋白偶联受体。视紫红质可以采用两种类型的四级结构。如果视紫红质折叠并获得适当的三级结构，则它可以在感光细胞膜内形成寡聚体和纳米域。相反，如果视紫红质错误折叠，它就不能通过生物合成途径进行，而是会形成聚集体，从而引起视网膜变性疾病。在这篇综述中，关于视紫红质在光感受器细胞膜内的超分子组织以及视紫红质的聚集会导致视网膜变性的观点得到了强调。