A recent systematic review (SR) and meta-analysis of human studies found an association between prenatal serum polybrominated diphenyl ethers (PBDE) concentrations and a decrease in the IQ of children. A SR of experimental developmental animal PBDE-mediated neurotoxicity studies was performed in the present study. Outcomes assessed included measures related to learning, memory, and attention, which parallel the intelligence-related outcomes evaluated in the human studies SR. PubMed, Embase, and Toxline were searched for relevant experimental non-human mammalian studies. Evaluation of risk of bias (RoB) and overall body of evidence followed guidance developed by the National Toxicology Program. Animal studies using varying designs and outcomes were available for BDEs 47, 99, 153, 203, 206, and 209 and the technical mixture DE-71. Study reporting of methods and results was often incomplete leading to concerns regarding RoB. A meta-analysis of 6 Morris water maze studies showed evidence of a significant increase in last trial latency (effect size of 25.8 [CI, 20.3 to 31.2]) in PBDE-exposed animals with low heterogeneity. For most endpoints, there were unexplained inconsistencies across studies and no consistent evidence of a dose-response relationship. There is a "moderate" level of evidence that exposure to BDEs 47, 99, and 209 affects learning. For other PBDEs and other endpoints, the level of evidence was "low" or "very low". The meta-analysis led to stronger conclusions than that based upon a qualitative review of the evidence. The SR also identified RoB concerns that might be remedied by better study reporting.

中文翻译：

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多溴二苯醚（PBDE）神经毒性：动物证据的系统回顾和荟萃分析。

最近的一项系统评价（SR）和人类研究荟萃分析发现，产前血清多溴二苯醚（PBDE）浓度与儿童智商下降之间存在关联。本研究进行了实验发育动物 PBDE 介导的神经毒性研究的 SR。评估的结果包括与学习、记忆和注意力相关的测量结果，这与人类研究 SR 中评估的智力相关结果相似。在 PubMed、Embase 和 Toxline 中搜索了相关的非人类哺乳动物实验研究。偏倚风险 (RoB) 和整体证据的评估遵循国家毒理学计划制定的指导。针对 BDE 47、99、153、203、206 和 209 以及技术混合物 DE-71，进行了使用不同设计和结果的动物研究。方法和结果的研究报告通常不完整，导致人们对 RoB 产生担忧。对 6 项 Morris 水迷宫研究的荟萃分析显示，有证据表明，在低异质性的 PBDE 暴露动物中，最后试验潜伏期显着增加（效应大小为 25.8 [CI，20.3 至 31.2]）。对于大多数终点，研究之间存在无法解释的不一致，并且没有剂量反应关系的一致证据。有“中等”水平的证据表明接触 BDE 47、99 和 209 会影响学习。对于其他多溴联苯醚和其他终点，证据水平为“低”或“非常低”。荟萃分析得出的结论比基于证据定性审查的结论更强。SR 还确定了可以通过更好的研究报告来解决的 RoB 问题。