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Combined findings of FDG-PET and arterial spin labeling in sporadic Creutzfeldt-Jakob disease.
Prion ( IF 2.3 ) Pub Date : 2018-10-09 , DOI: 10.1080/19336896.2018.1525255
Junliang Yuan 1 , Shuangkun Wang 2 , Wenli Hu 1
Affiliation  

Sporadic Creutzfeldt-Jakob disease (sCJD) is a fatal progressive neurodegenerative disease. Multimodal approaches, including electroencephalogram, diffusion-weighted imaging (DWI) of brain MRI, and cerebrospinal fluid biomarkers, have been applied to increase the diagnostic accuracy of sCJD. Although previous studies suggested DWI could be the most useful modality for sCJD diagnosis, whether metabolism changes underlying in sCJD are still poorly understood. To the best of our knowledge, there are only one case using the technique of arterial spin labeling (ASL) to detection and follow-up of perfusion changes in CJD. Herein, we described a 71-year-old woman presented with progressive cognitive decline, behavioral and psychological symptoms for two months. The patient died one month later after her admission. As far as we know, this is the first report using the combination of fluorodeoxyglucose positron emission tomography and ASL to explore the metabolism changes in sCJD. Our case exemplifies the difficulty clinicians may face in the diagnosis of sCJD.



中文翻译:

FDG-PET和动脉自旋标记在散发性Creutzfeldt-Jakob病中的综合发现。

偶发性Creutzfeldt-Jakob病(sCJD)是一种致命的进行性神经退行性疾病。多模式方法,包括脑电图,脑MRI的弥散加权成像(DWI)和脑脊液生物标记物,已被用于提高sCJD的诊断准确性。尽管先前的研究表明DWI可能是sCJD诊断的最有用方法,但对于sCJD中潜在的代谢变化是否仍然知之甚少。据我们所知,只有一种情况使用动脉自旋标记(ASL)技术来检测和随访CJD的灌注变化。本文中,我们描述了一名71岁的女性,该女性在两个月内出现进行性认知下降,行为和心理症状。患者入院一个月后死亡。据我们所知,这是首次结合氟脱氧葡萄糖正电子发射断层显像和ASL来探讨sCJD代谢变化的报告。我们的案例说明了临床医生在sCJD诊断中可能面临的困难。

更新日期:2018-10-09
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