Minimal hepatic encephalopathy (MHE) is highly prevalent, observed in up to 80% of patients with liver dysfunction. Minimal hepatic encephalopathy is defined as hepatic encephalopathy with cognitive deficits and no grossly evident neurologic abnormalities. Clinical management may be delayed due to the lack of in vivo quantitative methods needed to reveal changes in brain neurobiochemical biomarkers. To gain insight into the development of alcoholic liver disease-induced neurological dysfunction (NDF), a mouse model of late-stage alcoholic liver fibrosis (LALF) was used to investigate changes in neurochemical levels in the thalamus and hippocampus that relate to behavioral changes. Proton magnetic resonance spectroscopy of the brain and behavioral testing were performed to determine neurochemical alterations and their relationships to behavioral changes in LALF. Glutamine levels were higher in both the thalamus and hippocampus of alcohol-treated mice than in controls. Thalamic levels of taurine and creatine were significantly diminished and strongly correlated with alcohol-induced behavioral changes. Chronic long-term alcohol consumption gives rise to advanced liver fibrosis, neurochemical changes in the nuclei, and behavioral changes which may be linked to NDF. Magnetic resonance spectroscopy represents a sensitive and noninvasive measurement of pathological alterations in the brain, which may provide insight into the pathogenesis underlying the development of MHE.

中文翻译：

---

丘脑中牛磺酸和肌酸的减少可能与乙醇喂养小鼠的行为障碍有关：质子磁共振波谱的初步研究。

最小的肝性脑病（MHE）非常普遍，在多达80％的肝功能不全患者中观察到。最小型肝性脑病定义为具有认知缺陷且无明显神经系统异常的肝性脑病。由于缺乏揭示大脑神经生化生物标志物变化所需的体内定量方法，临床治疗可能会延迟。为了深入了解酒精性肝病引起的神经功能障碍（NDF）的发展，使用了晚期酒精性肝纤维化（LALF）的小鼠模型来研究与行为变化有关的丘脑和海马神经化学水平的变化。进行了大脑的质子磁共振波谱和行为测试，以确定神经化学变化及其与LALF行为变化的关系。酒精处理的小鼠的丘脑和海马中的谷氨酰胺水平均高于对照组。牛磺酸和肌酸的丘脑水平显着降低，并且与酒精引起的行为改变密切相关。长期长期饮酒会导致晚期肝纤维化，细胞核神经化学变化以及可能与NDF相关的行为变化。磁共振波谱代表对脑部病理变化的灵敏且非侵入性的测量，可为深入了解MHE的发病机理提供依据。酒精处理的小鼠的丘脑和海马中的谷氨酰胺水平均高于对照组。牛磺酸和肌酸的丘脑水平显着降低，并且与酒精引起的行为改变密切相关。长期长期饮酒会导致晚期肝纤维化，细胞核神经化学变化以及行为变化，这些变化可能与NDF有关。磁共振波谱代表对脑部病理变化的灵敏且非侵入性的测量，可为深入了解MHE的发病机理提供依据。酒精处理的小鼠的丘脑和海马中的谷氨酰胺水平均高于对照组。牛磺酸和肌酸的丘脑水平显着降低，并且与酒精引起的行为改变密切相关。长期长期饮酒会导致晚期肝纤维化，细胞核神经化学变化以及行为变化，这些变化可能与NDF有关。磁共振波谱代表对脑部病理变化的灵敏且非侵入性的测量，可为深入了解MHE的发病机理提供依据。长期长期饮酒会导致晚期肝纤维化，细胞核神经化学变化以及行为变化，这些变化可能与NDF有关。磁共振波谱代表对脑部病理变化的灵敏且非侵入性的测量，可为深入了解MHE的发病机理提供依据。长期长期饮酒会导致晚期肝纤维化，细胞核神经化学变化以及可能与NDF相关的行为变化。磁共振波谱代表对脑部病理变化的灵敏且非侵入性的测量，可为深入了解MHE的发病机理提供依据。