The discovery of tissue-resident innate lymphoid cell populations effecting different forms of type 1, 2, and 3 immunity; tissue repair; and immune regulation has transformed our understanding of mucosal immunity and allergy. The emerging complexity of these populations along with compounding issues of redundancy and plasticity raise intriguing questions about their precise lineage relationship. Here we review advances in mapping the emergence of these lineages from early lymphoid precursors. We discuss the identification of a common innate lymphoid cell precursor characterized by transient expression of the transcription factor PLZF, and the lineage relationships of innate lymphoid cells with conventional natural killer cells and lymphoid tissue inducer cells. We also review the rapidly growing understanding of the network of transcription factors that direct the development of these lineages.

中文翻译：

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先天性淋巴细胞前体。

发现组织驻留的先天性淋巴样细胞群体影响不同形式的1、2和3型免疫；组织修复；免疫调节已经改变了我们对粘膜免疫和过敏的认识。这些种群的新出现的复杂性，以及冗余和可塑性的复合问题，引发了有关其精确血统关系的有趣问题。在这里，我们回顾了从早期淋巴样前体映射这些谱系的出现的进展。我们讨论以转录因子PLZF的瞬时表达为特征的常见先天淋巴样细胞前体的鉴定，以及先天性淋巴样细胞与常规自然杀伤细胞和淋巴样组织诱导细胞的谱系关系。