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The social lives of migrating cells in Drosophila.
Current Opinion in Genetics & Development ( IF 4 ) Pub Date : 2006-06-21 , DOI: 10.1016/j.gde.2006.06.010
Denise J Montell 1
Affiliation  

Studies of cell migration in Drosophila are yielding insights into the complex interactions migrating cells have with each other and with the cells in their environment. Intriguing links between factors that promote cell migration and those that control cell survival have been reported recently. For example, migrating germ cells compete with the surrounding somatic tissue for the substrate of the lipid phosphate phosphatases encoded by the genes Wunen and Wunen2. Germ cells take up the dephosphorylated lipid and require it for their survival. In addition, the secreted growth factors called PVFs, previously thought to guide the migrations of hemocytes in the embryo, were found to function instead predominantly as survival factors. And in border cells, DIAP1 and Dronc, two proteins known mainly for their ability to regulate cell death, were found to control cell migration.

中文翻译:

果蝇中迁移细胞的社会生活。

对果蝇细胞迁移的研究正在深入了解迁移细胞之间以及与环境中的细胞之间的复杂相互作用。最近报道了促进细胞迁移的因素和控制细胞存活的因素之间的有趣联系。例如,迁移的生殖细胞与周围的体细胞组织竞争由基因 Wunen 和 Wunen2 编码的脂质磷酸酶的底物。生殖细胞吸收去磷酸化的脂质并需要它来生存。此外,以前被认为指导胚胎中血细胞迁移的称为 PVF 的分泌生长因子被发现主要作为生存因子发挥作用。在边界细胞中,DIAP1 和 Dronc 这两种蛋白质主要以调节细胞死亡的能力而闻名,
更新日期:2019-11-01
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