The impact of oral supplementation with an effervescent glutamine formulation on the beneficial effects of antiretroviral therapies was evaluated in people living with HIV/AIDS. For this purpose, 12 HIV/AIDS carrier patients with CD4⁺ T cell counts <500, and who had received the same antiretroviral therapy for at least 1 year before starting this investigation were selected. The patients were required to dissolve the effervescent glutamine formulation (supplied in sachets) in water immediately before oral ingestion (12.4 g), once a day, after lunch or after dinner during 30 days. CD4⁺ T cell counts, complete blood cell counts, serum cytokines, and amino acids levels were quantified; biochemical and toxicological measurements were performed. The numbers of CD4⁺ T cells were increased (P < .05), and the serum C-reactive protein levels decreased (P < .01) after the administration of effervescent glutamine formulation. Serum levels of interferon-gamma inducible protein-10, RANTES, and macrophage inflammatory protein-1β were decreased after the treatment with effervescent glutamine formulation. No changes were observed in the serum levels of amino acids, hematological, toxicological, and biochemical parameters. In conclusion, the treatment during 30 days with effervescent glutamine formulation was well tolerated, promoted reduction of inflammation, and improved the beneficial effects of antiretroviral therapies in HIV/AIDS carrier patients.

中文翻译：

---

谷氨酰胺泡腾剂制剂可提高抗逆转录病毒疗法对HIV / AIDS携带者免疫功能的有益作用。

在艾滋病毒/艾滋病患者中，评估了口服谷氨酰胺泡腾剂补充剂对抗逆转录病毒疗法有益效果的影响。为此，选择了12名HIV / AIDS携带者患者，其CD4 ⁺ T细胞计数<500，并且在开始这项研究之前至少接受了一年的抗逆转录病毒治疗。要求患者在口服（12.4 g）之前，每天一次，午餐后或晚餐后30天内将起泡的谷氨酰胺制剂（以小袋提供）溶于水。定量CD4 ⁺ T细胞计数，全血细胞计数，血清细胞因子和氨基酸水平；进行了生化和毒理学测量。CD4 ⁺的数量 服用泡腾型谷氨酰胺制剂后，T细胞增加（P  <.05），血清C反应蛋白水平降低（P <.01）。用泡腾型谷氨酰胺制剂治疗后，血清γ-干扰素诱导型蛋白10，RANTES和巨噬细胞炎性蛋白-1β水平降低。血清氨基酸水平，血液学，毒理学和生化指标未见变化。总之，在30天内使用泡腾谷氨酰胺制剂的治疗耐受性良好，促进了炎症减轻，并提高了抗逆转录病毒疗法对HIV / AIDS携带者的有益作用。