Alzheimer Disease & Associated Disorders ( IF 2.1 ) Pub Date : 2020-04-01 , DOI: 10.1097/wad.0000000000000358 Monica Cations 1, 2 , Adrienne Withall 1 , Lee-Fay Low 3 , Kylie Radford 4, 5 , Julian Trollor 6, 7 , Henry Brodaty 2, 6, 8 , Perminder Sachdev 2, 6, 9 , Peter Gonski 1, 10 , Gerald Anthony Broe 4, 5 , Robert G Cumming 11 , Brian Draper 2, 8
Introduction:
Both genetic and nongenetic factors contribute to the risk profile of young onset dementia (YOD), but risk factors often co-occur. This matched case-control study examined whether nongenetic risk factors cluster together, to inform targeted prevention efforts.
Methods:
Ninety-six participants with non–autosomal-dominant degenerative and/or vascular YOD and 175 controls were recruited to 2 Australian epidemiological studies. Risk exposure was retrospectively self-reported and/or informant-reported.
Results:
Each additional exposure increased the risk for YOD, though only where vascular dementia was included in the analysis. Cluster analysis identified 4 risk groups, one of which reported a high probability of exposure to all risks and a significantly higher risk for YOD.
Discussion:
Results suggest that combinations of nongenetic risk factors confer more risk for young onset vascular dementia, and possibly primary degenerative YOD, than a single factor on its own. Compared with their same-age peers, some people with YOD experience a lifetime of risk exposure starting from early in life.
中文翻译:
非常染色体显性退化性和血管性年轻发作性痴呆中非遗传危险因素的聚类和累加效应。
介绍:
遗传和非遗传因素造成的风险的轮廓年轻发性痴呆(YOD),但风险因素往往同时出现。这项匹配的病例对照研究检查了非遗传危险因素是否聚集在一起,以指导有针对性的预防工作。
方法:
参加研究的2项澳大利亚流行病学研究共纳入96名非常染色体显着性和/或血管性YOD的参与者和175名对照。风险暴露是回顾性自我报告和/或线人报告。
结果:
尽管仅在分析中包括血管性痴呆的情况下,每次额外的暴露都会增加发生YOD的风险。聚类分析确定了4个风险组,其中一组报告了暴露于所有风险的可能性很高,而YOD风险则明显更高。
讨论:
结果表明,与非单一因素相比,非遗传危险因素的组合给年轻发作的血管性痴呆和可能的原发性退行性YOD带来的风险更高。与同龄同龄人相比,有些YOD人从一开始就经历了一生的风险暴露。