Medicinal mineral water, being provided by recognized immunosuppressive properties, results useful for treating many pathological conditions. A well-known source of sulfurous and oligomer medicinal mineral waters is located in Caramanico Terme (Pescara, Italy). Caramanico Terme is a small town in the Majella's National Park, and its precious and peculiar environment offers a medicinal mineral water (also known as cures or crenotherapy), that since 1576 is administrated to a large number of patients (around 15,000 per year). However, no scientific conclusions on the efficacy of Caramanico's Terme medicinal mineral water properties are available. Therefore, we have carried out an epidemiological study, enrolling a population of 370 subjects that have received crenotherapy. Such a population has been also compared to a control group of individuals (untreated, N = 287), never undergone any medicinal mineral water administration. Detailing the geomorphological characteristics of Caramanico Terme environment, we have also analyzed the results of the study that showed that pathology-relapses, as well as related manifestations of symptoms and drug employments, were largely reduced after one or more cycles of crenotherapy. On the other hand, a sub-group of subjects receiving crenotherapy for more than 5 years (N = 166) presented a highly reduced prevalence of a large spectrum of pathologies (cardiovascular, inflammatory, neurological and cancer diseases), with respect to an overlapping population (in terms of age and genders) of untreated subjects. We have also clarified the role of aging and long-term effects of medicinal mineral-water administration. Altogether, these data indicated that the clinical employment of Caramanico's Terme medicinal mineral water produces short- as well as long-term beneficial effects, both with respect to the amelioration of life quality of patients and in reducing the probability to develop major disabling pathologies (i.e., cardiovascular, cancer and neurological diseases). Therefore, these data will open novel strategies for a larger application of crenotherapy.

中文翻译：

---

药用矿泉水管理的短期和长期有益作用。

药用矿泉水具有公认的免疫抑制特性，可用于治疗许多病理状况。著名的含硫和低聚物药用矿泉水来源位于卡拉马尼科泰尔梅（意大利佩斯卡拉）。Caramanico Terme是马耶拉国家公园中的一个小镇，其珍贵而独特的环境提供了药用矿泉水（也称为治愈或深冷疗法），自1576年以来就向大量患者（每年约15,000人）给药。但是，尚无关于Caramanico的Terme药用矿泉水性能功效的科学结论。因此，我们进行了一项流行病学研究，招募了370位接受开颅疗法的受试者。还将该人口与从未接受过任何药用矿泉水管理的对照组（未治疗，N = 287）进行了比较。详细介绍了Caramanico Terme环境的地貌特征，我们还分析了研究结果，该研究结果显示，经过一个或多个深疗后，病理学复发以及症状和药物使用的相关表现大大降低。另一方面，接受重叠疗法超过5年（N = 166）的亚组受试者在重叠方面相对于多种病理（心血管，炎症，神经和癌症疾病）患病率大大降低未经治疗的受试者的人数（年龄和性别）。我们还阐明了矿物质水管理的衰老作用和长期影响。总而言之，这些数据表明，在改善患者的生活质量以及减少发展重大致残性疾病的可能性方面，卡拉曼尼科（Caramanico）的Terme药用矿泉水的临床使用产生了短期和长期的有益效果。 ，心血管，癌症和神经系统疾病）。因此，这些数据将为颅骨疗法的更大应用开辟新的策略。既可以改善患者的生活质量，又可以减少发展主要致残性疾病（即心血管，癌症和神经系统疾病）的可能性。因此，这些数据将为颅骨疗法的更大应用开辟新的策略。既可以改善患者的生活质量，又可以减少发展主要致残性疾病（如心血管疾病，癌症和神经系统疾病）的可能性。因此，这些数据将为颅骨疗法的更大应用开辟新的策略。