ABC transporters of the Pleiotropic Drug Resistance (PDR) family are the main actors of antifungal resistance in pathogenic fungi. While their involvement in clinical resistant strains has been proven, their transport mechanism remains unclear. Notably, one hallmark of PDR transporters is their asymmetry, with one canonical nucleotide-binding site capable of ATP hydrolysis while the other site is not. Recent publications reviewed here show that the so-called "deviant" site is of crucial importance for drug transport and is a step towards alleviating the mystery around the existence of non-catalytic binding sites.

中文翻译：

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病原真菌中的PDR样ABC系统。

多效性耐药性（PDR）家族的ABC转运蛋白是致病真菌中抗真菌耐药性的主要参与者。尽管已证明它们参与临床耐药菌株，但其转运机制仍不清楚。值得注意的是，PDR转运蛋白的一个标志是它们的不对称性，一个典型的核苷酸结合位点能够进行ATP水解，而另一个则不能。在此审查的最新出版物表明，所谓的“异常”位点对于药物运输至关重要，是朝着缓解围绕非催化结合位点的奥秘迈出的一步。