Micro-computed tomography (micro-CT) coupled with tissue, or vascular, specific contrast agent has emerged as a powerful tool for detecting and monitoring tumor growth in the liver of murine animals. Intravenous injections of contrast agents can be technically challenging and lead to errors that can considerably influence the outcome of a preclinical study, prompting an alternative method. Here we assessed the effectiveness of intraperitoneal injections of polyiodinated triglycerides emulsions (Fenestra LC) in micro-CT imaging of young SCID (8 weeks) and old BALB/c (48 weeks) mice with xenograft or carcinogen-induced liver tumors, respectively, and determined an optimal acquisition time. Utilizing an intraperitoneal injection is a viable alternative administration route for using Fenestra in detection and quantification of murine liver tumor burden.

中文翻译：

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腹腔注射作为微CT造影剂的替代方法可以增强对鼠肝肿瘤的检测。

微计算机断层扫描（micro-CT）结合组织或血管特异性造影剂已成为检测和监测鼠类动物肝脏肿瘤生长的强大工具。静脉注射造影剂在技术上可能具有挑战性，并导致可能严重影响临床前研究结果的错误，从而催生了另一种方法。在这里，我们评估了腹腔内注射聚碘化甘油三酸酯乳剂（Fenestra LC）在分别具有异种移植物或致癌物诱发的肝肿瘤的年轻SCID（8周）和年老BALB / c（48周）小鼠的微CT成像中的效果，确定最佳采集时间。